January 2026 in “Frontiers in Molecular Biosciences” The study presents a novel diagnostic framework for alopecia areata (AA) using a few-shot deep learning classifier that integrates bulk and single-cell RNA-seq data to analyze JAK–STAT signaling. Researchers identified 257 differentially expressed genes in AA, with four key genes—GZMA, IL2RB, IL2RG, and EOMES—validated as biomarkers. The framework uses MultiPLIER latent variables and a Relation-style set-to-set comparator to distinguish AA from controls, even with limited samples, while maintaining interpretability. Functional validation confirmed the activation of the IL2RB/IL2RG–EOMES–GZMA axis in AA, linked to JAK inhibitors and cyclosporine, unlike androgenetic alopecia (AGA), which lacks JAK–STAT perturbation. This approach offers a non-invasive biomarker and a target for precision JAK blockade, demonstrating an XAI-driven method for small-cohort genomic diagnosis.
January 1983 in “Journal of the American Oil Chemists' Society” The U.S. soybean industry wanted government help due to foreign competition, while the jojoba industry was growing and expected to stabilize.
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February 1998 in “Analytical Chemistry” Method detects finasteride in plasma at very low concentrations.
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September 2007 in “Cancer” Prostate cancer prevention includes diet changes, supplements, and medications, with more answers expected soon.
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June 2022 in “IEEE Journal of Biomedical and Health Informatics” The new method improves skin cancer detection in imbalanced datasets.