Dermal FOXO3 Activity in Response to Wnt/β-Catenin Signaling Is Required for Feather Follicle Development of Goose Embryos (Anser Cygnoides)

January 2024 in “ Poultry Science ”

Sihui Wang, Yu Wang, Xiangman Hu, Yuxuan Zhou, Zhiyi Yang, Jiahui Hou, Fengshuo Liu, Qiuyuan Liu, Ichraf Mabrouk, Jin Yü, Xinyue Li, Guizhen Xue, Yongfeng Sun

TLDR FOXO3 is essential for proper feather development in goose embryos.

This study investigates the role of FOXO3 in feather follicle development in goose embryos, highlighting its importance in the economic value of poultry. The research demonstrates that FOXO3 activity in dermal fibroblasts is crucial for regulating the Wnt/β-catenin signaling pathway, which in turn affects feather follicle formation and development. In vitro experiments showed that altering FOXO3 expression led to significant changes in feather morphology, such as length, width, and follicle diameter, without affecting follicle density. The findings underscore the critical role of FOXO3 in dermal fibroblasts for proper feather follicle development during the embryonic stage.

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