Enigma of Folliculitis Decalvans in Two Pediatric Sisters Treated with Low-Dose Isotretinoin and Erythromycin

    May 2025 in “ Medical Journal of Dr D Y Patil Vidyapeeth ”
    Amogh Ratnaparkhi, Praneet Awake, Anand Bhosale, Prabodh Gaikwad, Neeta Gokhale, Aditi Shende, Vivek Dugad, Rajan Bindu, Prateek Awake, Shruti Dewang
    Image of study
    TLDR Low-dose isotretinoin and erythromycin effectively treated hair loss in two young sisters.
    This case report discusses a rare occurrence of folliculitis decalvans (FD) in two young sisters, aged 5 and 3, who were effectively treated with low-dose isotretinoin and erythromycin. FD is a type of cicatricial alopecia marked by chronic inflammation and hair follicle destruction, and it is rare in children. The sisters showed patchy hair loss but experienced significant hair regrowth and sustained remission after a 3-month treatment. The study suggests isotretinoin as a promising treatment for FD due to its immunomodulatory and anti-inflammatory effects, providing an alternative or complement to antimicrobials.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 99 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Going to try and reverse MPB naturally.

      in Treatment  55 upvotes 3 years ago
      A user is trying to reverse male pattern baldness (MPB) naturally by taking high doses of Vitamin D, improving diet, exercising, reducing stress, and other lifestyle changes, but plans to use finasteride if no results are seen in 60 days. Other users are skeptical, advising medical treatments like finasteride and warning against potential vitamin D overdose and the ineffectiveness of natural remedies for genetic hair loss.

      community I tried salt water to stop the DHT itch

      in Treatment  58 upvotes 3 years ago
      Treating the itch associated with male pattern baldness, which is believed to be caused by DHT. Potential treatments discussed include salt water, finasteride, ketoconazole, and RU58841.

    Similar Research

    5 / 1000+ results
      Cicatricial Alopecias

      research Cicatricial Alopecias

      May 2017 in “InTech eBooks”
      Some hair loss disorders cause permanent loss due to scarring, and treatments like steroids don't always work well.
      Primary Cicatricial Alopecia

      research Primary Cicatricial Alopecia

      65 citations , November 2016 in “Journal of The American Academy of Dermatology”
      The document concludes that early recognition and treatment of primary cicatricial alopecia is crucial to prevent permanent hair loss.
      Primary Cicatricial Alopecias

      research Primary Cicatricial Alopecias

      1 citations , April 2010 in “Expert Review of Dermatology”
      The document concludes that early diagnosis and treatment are crucial for managing rare hair loss disorders and that more research is needed to improve treatment strategies.