Fetal Fibroblast Heterogeneity Defines Dermal Architecture During Human Embryonic Skin Development

    January 2025 in “ Journal of Investigative Dermatology ”
    Noriko Morioka, Clarisse Gânier, Fiona M. Watt
    Studysummary In this study, researchers analyzing human fetal skin fibroblasts found eight distinct populations with developmental stage-specific abundance, identifying markers linked to fibroblast functions in blood vessel development, dermal layers, and hair follicle maturation.
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    Research cited in this study 9

    1. Multiscale Spatial Mapping of Cell Populations Across Anatomical Sites in Healthy Human Skin and Basal Cell Carcinoma Proceedings of the National Academy of Sciences of the United States of America · 2024
    2. Fibroblast Heterogeneity in Healthy and Wounded Skin Cold Spring Harbor Perspectives in Biology · 2022
    3. Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing Molecular Systems Biology · 2018
    4. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    5. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    6. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth Journal of Investigative Dermatology · 2017
    7. Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation Journal of Investigative Dermatology · 2015
    8. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    9. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011