Advances in Extraction Technologies of Silybum Marianum L. and Its Role in Protecting Against Skin Damage

September 2025 in “ Cosmetics ”

Oumayma Iraqi, Mariam Jalal, Issam El Mouzazi, Mourad Jbene, Youness Taboz, Amar Habsaoui

Silybum marianum milk thistle silymarin photoaging acne wound healing UV damage Nrf2 extracellular matrix

TLDR Milk thistle can protect skin from damage and aging.

The document reviews the protective effects of Silybum marianum (milk thistle) on skin health, emphasizing its potential in treating skin aging, acne, hair loss, wound healing, and skin cancer. Silymarin, a key compound, reduces oxidative stress, enhances collagen synthesis, and improves skin hydration and elasticity. It also shows anti-inflammatory and antioxidant properties, aiding in acne management and hair growth. Silymarin accelerates wound healing and exhibits chemopreventive effects in skin cancer models. The review highlights advancements in extraction technologies, such as enzyme-assisted and supercritical CO2 extraction, which enhance silymarin yield. Despite promising results, further clinical studies and sustainable extraction methods are needed to maximize therapeutic benefits and ensure safety.

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Advances in Extraction Technologies of Silybum Marianum L. and Its Role in Protecting Against Skin Damage

Research cited in this study

research A Well-Tolerated Hair Serum Containing New Natural Active Ingredients Reduced Hair Loss and Improved Quality of Life in Women With Chronic Telogen Effluvium: A 16-Week Controlled Study

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research Evaluation of Efficacy of Silybum Marianum Flower Extract on Mitigating Hair Loss In Vitro and In Vivo

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research Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/β-Catenin Signaling Activation in 3-Dimensional Spheroid Cultured Human Dermal Papilla Cells

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

research New Developments in Our Understanding of Acne Pathogenesis and Treatment

research Molecular Mechanisms of Androgenetic Alopecia

research The Psychological Effects of Androgenetic Alopecia in Men

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