Exosome-Based Therapies for Alopecia: A Systematic Review of Clinical Efficacy and Safety

    March 2026 in “ International Society of Hair Restoration Surgery ”
    Fabianna Acerbi Penha, Giovanna Acerbi Penha, Helena Maria Caleiro Acerbi
    Studysummary In this study, researchers systematically reviewed the clinical outcomes of exosome-based therapies for alopecia, reporting promising but low-certainty evidence of improvements in hair density and thickness, with mainly mild adverse effects, and highlighting the need for larger, well-designed trials.
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    Research cited in this study 13

    1. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway Stem Cell Research & Therapy · 2025
    2. A Comprehensive Literature Review: The Potential of Exosomes in Hair Growth and Transplantation International Society of Hair Restoration Surgery · 2025
    3. Platelet-Rich Plasma-Derived Exosomes Stimulate Hair Follicle Growth Through Activation of the Wnt/β-Catenin Signaling Pathway Regenerative Therapy · 2025
    4. A Prospective Study of Exosome Therapy for Androgenetic Alopecia Aesthetic Plastic Surgery · 2025
    5. Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study Aesthetic Plastic Surgery · 2024
    6. Improvement of Androgenic Alopecia by Extracellular Vesicles Secreted from Hyaluronic Acid-Stimulated Induced Mesenchymal Stem Cells Stem Cell Research & Therapy · 2024
    7. The Efficacy of Adipose Stem Cell-Derived Exosomes in Hair Regeneration Based on a Preclinical and Clinical Study International Journal of Dermatology · 2024
    8. Clinical Use of Extracellular Vesicles in the Management of Male and Female Pattern Hair Loss: A Preliminary Retrospective Institutional Review Board Safety and Efficacy Study Aesthetic surgery journal · 2022
    9. A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia Stem Cells Translational Medicine · 2020
    10. Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy International Journal of Molecular Sciences · 2020
    11. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    12. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    13. The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride Journal of Dermatological Treatment · 2013