Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness
May 2015
in “
PLOS ONE
”
TLDR DNA variants can predict male pattern baldness, with higher risk scores increasing baldness likelihood.
This study evaluated the potential of DNA variants to predict male pattern baldness (MPB) and identified multiple genetic loci with small individual effects that contribute to the overall risk of developing MPB. The study found that individuals carrying seven or more MPB risk alleles are significantly more susceptible to MPB, and a genotype risk score calculated from the combined weighted number of risk alleles for these loci shows males with the highest genotype scores have a three-fold increased MPB risk. The study also developed a 20-SNP prediction model that achieved an overall correct prediction rate of 88.5% for 65% threshold, with the highest level of correct predictions recorded for males with Norwood-Hamilton V-VII grades of baldness. The study suggests that MPB is a heterogeneous phenotype and early onset and later onset alopecia could have different genetic backgrounds.
View this study on journals.plos.org →
Cited in this study
17 / NoResults
research Age-related hair changes in men: Mechanisms and management of alopecia and graying
Men's hair loss is caused by hormones and genes, and can be treated with medication and surgery, while graying is due to aging and has no prevention except dyeing.
research Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles
The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.
research Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population
Genetic variants at 20p11 increase baldness risk in Chinese Han people.
research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology
Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.
research Characteristics of Androgenetic Alopecia in Asian
Asian hair loss differs from Europeans; consider individual needs and psychological well-being for treatment.
research Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss
AR/EDA2R gene linked to early-onset female hair loss, but 20p11 gene not involved.
research Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases
Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.
research Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis
G allele of AR Stul polymorphism linked to higher hair loss risk, especially in white people.
research Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness
A gene called HDAC9 might be a new factor in male-pattern baldness.
research Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene
Two gene areas linked to male pattern baldness found, more research needed.
research Fine mapping of the human AR/EDA2R locus in androgenetic alopecia
Genetic marker rs12558842 strongly linked to male hair loss.
research Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans
Common variants in the Trichohyalin gene are linked to straight hair in Europeans.
research Male-pattern baldness susceptibility locus at 20p11
Researchers found a new gene area linked to male-pattern baldness, which, along with another gene, significantly increases the risk of hair loss in men.
research EDA2R Is Associated with Androgenetic Alopecia
EDA2R gene linked to hair loss.
research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia
Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
research The E211 G>A Androgen Receptor Polymorphism Is Associated with a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia
E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.
research Prevalence of Male Pattern Hair Loss in 18–49 Year Old Men
Hair loss is more common in men aged 18-49 and increases with age.
Related
1 / NoResults
research Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness
DNA variants can predict male pattern baldness, with higher risk scores increasing baldness likelihood.