Enzymatic and Non-Enzymatic Sulfation Mechanisms in the Biological Actions of Minoxidil

    January 1993 in “ Biochemical Pharmacology ”
    Kaushik D. Meisheri, Garland A. Johnson, Lynn Puddington
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    TLDR Minoxidil needs activation to work, and minoxidil sulfate helps with hair growth and blood pressure.
    This 30-year-old document discusses the mechanisms behind the biological actions of minoxidil, a drug originally developed for hypertension but later found to stimulate hair growth. The study found that metabolic activation of minoxidil is required for its biological activity, and the identification of minoxidil sulfate as a naturally occurring metabolite confirmed this hypothesis. The study also discusses the cellular mechanism of action of minoxidil sulfate as a vasodilator antihypertensive agent. The paper highlights two major areas of interest for minoxidil research: the characterization of minoxidil sulfotransferase, an enzyme responsible for the bioactivation of minoxidil, and the cellular and molecular mechanisms involved in the actions of minoxidil sulfate.
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      Can liver problems be associated with response to the oral minoxidil?

      community Can liver problems be associated with response to the oral minoxidil?

      in Research  147 upvotes 4 days ago
      Liver problems may reduce the effectiveness of oral minoxidil due to impaired SULT1A1 enzyme activity, which is crucial for converting minoxidil to its active form. This reduction in enzyme function can significantly decrease the drug's effectiveness in promoting hair growth.

      community Is this Better Than Topical Minoxidil? Topical Diazoxide

      in Research/Science  6 upvotes 9 months ago
      Topical diazoxide may be a promising hair regrowth treatment, especially for those who don't respond to minoxidil, as it activates potassium channels without needing sulfation. It appears safe for topical use, avoiding systemic effects seen in oral use.

      community Minoxidil Sulfate makes everyone a responder

      in Research/Science  259 upvotes 1 year ago
      Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

      community Comprehensive Microneedling Guide

      in Microneedling  289 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

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