Exploring the Efficacy and Safety of Topical Phenytoin in Androgenetic Alopecia: A Clinical Investigation

    June 2026 in “ Journal of Cosmetic Dermatology ”
    Sina Maskoukian, Atefeh Naeimifar, Aniseh Samadi … Alireza Firooz
    Studysummary This study found that a topical 5% phenytoin solution, applied twice daily for 16 weeks, significantly improved total hair count and hair density in men with androgenetic alopecia, with mild and transient side effects observed.
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    Research cited in this study 8

    1. Physiopathology and Current Treatments of Androgenetic Alopecia: Going Beyond Androgens and Anti-Androgens Dermatologic Therapy · 2019
    2. Hirsutism Obstetrics, gynaecology and reproductive medicine · 2008
    3. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
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    5. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    6. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    7. Treatment of Hair Loss The New England Journal of Medicine · 1999
    8. Topical Minoxidil in Early Male Pattern Baldness Journal of The American Academy of Dermatology · 1985