Efficacy and Safety of Topical Adenosine for Androgenetic Alopecia in Adults: A Systematic Review

June 2020 in “ Acta medica Philippina ”

Blythe N. Ke, Juan Antonio Millón Villena, Ma. Lorna F. Frez

topical adenosine androgenetic alopecia AGA topical niacinamide topical minoxidil placebo thick hair ratio adenosine niacinamide minoxidil Rogaine

TLDR Topical adenosine may effectively and safely treat hair loss.

This systematic review evaluated the efficacy and safety of topical adenosine for treating androgenetic alopecia (AGA) in adults. It included four trials with a total of 260 participants who used 0.75% topical adenosine lotion twice daily for 6-12 months. Comparators were placebo, topical niacinamide, and topical minoxidil. Results showed significant improvement in the thick hair ratio and higher participant satisfaction with topical adenosine. Few to no adverse effects were reported. The review concluded that topical adenosine might be an effective and safe adjunct or alternative treatment for AGA, though more studies are needed to confirm these findings.

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