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research Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study

40 citations , January 2013 in “Clinical Cosmetic and Investigational Dermatology”

In this study, niacinamide 4% and desonide 0.05% emulsions significantly improved axillary hyperpigmentation in women, with desonide demonstrating a superior depigmenting effect compared to niacinamide and placebo.

research Topical niacinamide does not stimulate hair growth based on the existing body of evidence

2 citations , January 2020 in “International Journal of Cosmetic Science”

In this in vitro study, niacinamide was found not to stimulate VEGF synthesis across a wide range of doses.

research Efficacy and Safety of Topical Adenosine for Androgenetic Alopecia in Adults: A Systematic Review

June 2020 in “Acta medica Philippina”

This research review suggests that topical adenosine could improve hair thickness and user satisfaction in adults with androgenetic alopecia, with minimal side effects reported, but concludes that further studies are necessary to confirm these findings.

research Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia

11 citations , April 2015 in “International Journal of Cosmetic Science”

This study found that topical adenosine significantly increased the ratio of thick hairs and contributed to global improvement in Japanese men with androgenetic alopecia compared to niacinamide, with no observed adverse events.

research Cyberspace Chat: An Examination of the Potential Benefits of Caffeine, Niacinamide, and Panthenol

September 2014 in “Hair transplant forum international”

This issue contains notes by Dr. Bradley Wolf and mentions comments by Dr. Jerry Cooley, but it presents no new research findings.

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Community Join

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community Hair Lotion Suggestion Needed!

3 upvotes 1 year ago

A user is seeking suggestions for a custom hair lotion mix containing minoxidil, finasteride, caffeine, niacinamide, and biotin. Another user suggests adding tretinoin, topical valproate, and bimatoprost.

community Topical finasteride carrier vehicle

1 upvotes 1 year ago

The user is using a topical solution containing 1% finasteride and 5% minoxidil for hair loss, with water, glycerin, and PEG-40 hydrogenated castor oil as carrier agents. They are questioning if these ingredients are effective carriers after using the solution for three months.

community topical finasteride: dissolving finasteride in "alpacin cafeine liquid"?

1 upvotes 2 years ago

A user discusses using Alpecin Caffeine Liquid for scalp health and considers dissolving finasteride tablets into it for a DIY topical treatment. They inquire about potential absorption issues with this method.

community Question regarding Topical finasteride solution

3 upvotes 1 year ago

A user is using a topical spray containing Finasteride 1% and Minoxidil 5% along with other ingredients like glycerin and aqua, questioning if these are effective carrier agents. They apply it once daily and use a separate 5% Minoxidil solution at night.

community Mix Alpezin liquid with topical finasteride

3 upvotes 2 years ago

The user cannot handle Minoxidil and is looking for an alternative to dilute topical finasteride. They are considering using Alpecin liquid as a solution.

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Learn

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learn Niacinamide

Is Niacinamide better to apply topically or to take as a supplement for hair growth? Neither topical nor oral niacinamide has been shown to grow hair. Topical niacinamide has been studied mainly on facial skin.

learn Adenosine

Adenosine: Is it true it works better for women than men? Why is that? No trial has ever compared topical adenosine in men against women directly, so the claim is unproven. Separate small Japanese trials — 30 women vs placebo over 12 months, 102 men vs niacinamide over 6 months — both reported more thick hairs, so the published evidence is positive in both sexes rather than clearly better in one.

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin mainly hydrates the hair and scalp; no study has shown that it increases hair thickness or changes follicle function.

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