Long-Term Effectiveness and Safety of Topical Finasteride 0.25% Monotherapy in Male Androgenetic Alopecia: A 52-Week Real-World Retrospective Study

    August 2026 in “ Clinical and Experimental Dermatology ”
    Giuseppe Gallo, Luca Mastorino, Pietro Quaglino, Simone Ribero
    Studysummary This study found that topical finasteride 0.25% monotherapy significantly increased hair density in men with androgenetic alopecia over one year, with minimal side effects and no reported systemic adverse events.
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    Research cited in this study 10

    1. Topical Tacrolimus, Clobetasol, and Minoxidil for Primary Cicatricial Alopecias: A Retrospective Analysis of Clinical Outcomes and Safety Skin Appendage Disorders · 2025
    2. Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment Drug Design Development and Therapy · 2025
    3. Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System International Journal of Dermatology · 2025
    4. No Increased Risk of Mood Disorders in Male Androgenetic Alopecia Patients Treated with Dutasteride and Finasteride: A Retrospective Cohort Database Study Journal of the American Academy of Dermatology · 2025
    5. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    6. Topical Finasteride for Male and Female Pattern Hair Loss: Is It a Safe and Effective Alternative? Journal of Cosmetic Dermatology · 2022
    7. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    8. Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls Clinical Interventions in Aging · 2021
    9. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    10. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002