Effect of Aloe Vera and Mentha Piperita Combination Serum on CDK1 and CDC25 Expression in Chemotherapy-Induced Alopecia Rats

    August 2025 in “ Tropical Journal of Natural Product Research ”
    S Handayani, Atina Hussaana, Titiek Sumarawati
    Studysummary This study found that mint leaf and Aloe vera serum together significantly reduced CDK1 expression, which may help prevent chemotherapy-induced alopecia in rats, although only mint serum alone reduced CDC25 expression.
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    Research cited in this study 12

    1. Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming? Current Oncology · 2023
    2. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    3. Preparation and Optimization of Aloe Ferox Gel Loaded with Finasteride-Oregano Oil Nanocubosomes for Treatment of Alopecia Drug Delivery · 2022
    4. Hair Growth-Promotion Effects at the Cellular Level and Antioxidant Activity of the Plant-Based Extract Phyllotex Heliyon · 2021
    5. Effect of Mesenchymal Stem Cells Versus Aloe Vera on Healing of Deep Second-Degree Burn Stem Cell Investigation · 2021
    6. A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL/6 Mice Pharmaceutics · 2020
    7. Prevention and Treatment of Chemotherapy-Induced Alopecia Dermatology practical & conceptual · 2020
    8. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    9. Chemotherapy-Induced Hair Loss: The Use of Biomarkers for Predicting Alopecic Severity and Treatment Efficacy Biomarker Insights · 2019
    10. Ethnopharmacological Survey of Home Remedies Used for Treatment of Hair and Scalp and Their Methods of Preparation in the West Bank, Palestine BMC complementary and alternative medicine · 2017
    11. Multi-Therapies in Androgenetic Alopecia: Review and Clinical Experiences Dermatologic Therapy · 2016
    12. Peppermint Oil Promotes Hair Growth Without Toxic Signs Toxicological Research · 2014