Topical Minoxidil and Dietary Supplement for the Treatment of Chemotherapy-Induced Alopecia in Childhood: A Retrospective Cohort Study

    February 2024 in “ Scientific Reports ”
    Ji Won Lee, Jeewoo Kang, Jung Yoon Choi … Oh Sang Kwon
    Studysummary In this retrospective cohort study, 87.1% of pediatric patients with chemotherapy-induced alopecia experienced clinical improvement after treatment with minoxidil or combination therapy with CYP, with the combination therapy showing greater hair thickness and minimal adverse effects.
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    Research cited in this study 21

    1. Efficacy of Low-Dose Oral Minoxidil in the Management of Anticancer Therapy-Induced Alopecia in Patients With Breast Cancer: A Retrospective Cohort Study Journal of The American Academy of Dermatology · 2022
    2. Aging of Hair Follicle Stem Cells and Their Niches Journal of Biochemistry and Molecular Biology · 2022
    3. Systemic Minoxidil for Hair Disorders in Pediatric Patients: A Safety and Tolerability Review International Journal of Dermatology · 2022
    4. Low-Dose Oral Minoxidil for Treatment of Androgenetic Alopecia and Telogen Effluvium in a Pediatric Population: A Descriptive Study Journal of The American Academy of Dermatology · 2022
    5. Permanent Chemotherapy-Induced Alopecia After Hematopoietic Stem Cell Transplantation Treated With Low-Dose Oral Minoxidil JAAD case reports · 2022
    6. Oral Minoxidil for Chemotherapy-Induced Alopecia Skin appendage disorders · 2022
    7. Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors JAMA Dermatology · 2021
    8. Assessment and Treatment Outcomes of Persistent Radiation-Induced Alopecia in Cancer Patients JAMA dermatology · 2020
    9. L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes Clinical, Cosmetic and Investigational Dermatology · 2020
    10. Topical and Oral Minoxidil for Hair Disorders in Pediatric Patients: What Do We Know So Far? Dermatologic Therapy · 2020
    11. Pediatric Androgenetic Alopecia: A Review Journal of The American Academy of Dermatology · 2019
    12. Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia JAMA Dermatology · 2019
    13. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019
    14. Comparative Evaluation Between Two Nutritional Supplements in the Improvement of Telogen Effluvium Clinical, Cosmetic and Investigational Dermatology · 2018
    15. Chemotherapy-Induced Alopecia Management: Clinical Experience and Practical Advice Journal of Cosmetic Dermatology · 2017
    16. Treatment of Permanent Chemotherapy-Induced Alopecia with Low Dose Oral Minoxidil Australasian Journal of Dermatology · 2015
    17. Dietary Supplement Increases Anagen Hair Rate in Women With Telogen Effluvium: Results of a Double-Blind, Placebo-Controlled Trial Therapy · 2006
    18. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    19. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    20. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    21. Minoxidil as a Prophylaxis of Doxorubicin-Induced Alopecia Annals of Oncology · 1994

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    1. Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2023
    2. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002