Effect of Cellular Blood Components on Chemotherapy-Induced Alopecia

September 2019 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Christina Stamatiou, Assuan Lens, Carmen Perez, Sylvia Daunert, Joaquín J. Jiménez

chemotherapy-induced alopecia Mononuclear Cells Platelet Rich Plasma Ara-C cyclophosphamide etoposide IL-1 alopecia CIA MC PRP CTX VP-16

TLDR Mononuclear cells may protect against certain chemotherapy-induced hair loss.

The study investigated the protective effects of Mononuclear Cells (MC) and Platelet Rich Plasma (PRP) on chemotherapy-induced alopecia (CIA) using a young rat model. Three chemotherapeutic agents were tested: Ara-C, cyclophosphamide (CTX), and etoposide (VP-16). The control group received PBS, while other groups received PRP or MC. All groups developed complete body alopecia. MC provided excellent protection against CIA induced by Ara-C, likely due to IL-1 release, but offered no protection against CTX or VP-16. PRP did not protect against any chemotherapeutic agents. The study concluded that specific blood cells, particularly MC, may offer protection from CIA depending on the chemotherapy used.

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