Effect of Cellular Blood Components on Chemotherapy-Induced Alopecia
September 2019
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
TLDR Mononuclear cells may protect against certain chemotherapy-induced hair loss.
The study investigated the protective effects of Mononuclear Cells (MC) and Platelet Rich Plasma (PRP) on chemotherapy-induced alopecia (CIA) using a young rat model. Three chemotherapeutic agents were tested: Ara-C, cyclophosphamide (CTX), and etoposide (VP-16). The control group received PBS, while other groups received PRP or MC. All groups developed complete body alopecia. MC provided excellent protection against CIA induced by Ara-C, likely due to IL-1 release, but offered no protection against CTX or VP-16. PRP did not protect against any chemotherapeutic agents. The study concluded that specific blood cells, particularly MC, may offer protection from CIA depending on the chemotherapy used.
