Retrospective Cohort Study of CDK4/6-Inhibitor-Induced Alopecia in Breast Cancer Patients

    November 2023 in “ Supportive Care in Cancer ”
    Abena Minta, Lucy Rose, Candice Park … Brittany Dulmage
    Studysummary This study found that breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapy experienced more pronounced vertex hair loss and were less responsive to minoxidil treatment compared to those on endocrine monotherapy.
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    Research cited in this study 15

    1. Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force Dermatology for Cancer Patients International Study Cancers · 2023
    2. Efficacy of Low-Dose Oral Minoxidil in the Management of Anticancer Therapy-Induced Alopecia in Patients With Breast Cancer: A Retrospective Cohort Study Journal of The American Academy of Dermatology · 2022
    3. Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia Journal of Dermatological Treatment · 2022
    4. Clinical Aspects, Pathogenesis, and Therapy Options of Alopecia Induced by Hormonal Therapy for Breast Cancer Exploration of targeted anti-tumor therapy · 2021
    5. Patient, Oncologist, And Payer Preferences For Adjuvant Endocrine Therapy And CDK4/6 Inhibitor Regimens In Early-Stage Breast Cancer: A Discrete Choice Experiment Patient Preference and Adherence · 2021
    6. A Novel Topical Combination of Minoxidil and Spironolactone for Androgenetic Alopecia: Clinical, Histopathological, and Physicochemical Study Dermatologic Therapy · 2020
    7. Spironolactone Use Does Not Increase the Risk of Female Breast Cancer Recurrence: A Retrospective Analysis Journal of The American Academy of Dermatology · 2020
    8. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    9. CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia EMBO Molecular Medicine · 2019
    10. CDK4/6 Plus Aromatase Inhibitor-Induced Alopecia in Breast Cancer Patients Journal of Clinical Oncology · 2019
    11. Safety of 5α-Reductase Inhibitors and Spironolactone in Breast Cancer Patients Receiving Endocrine Therapies Breast Cancer Research and Treatment · 2018
    12. Hair Disorders in Patients with Cancer Journal of The American Academy of Dermatology · 2018
    13. Endocrine Therapy-Induced Alopecia in Patients With Breast Cancer JAMA Dermatology · 2018
    14. Alopecia With Endocrine Therapies in Patients With Cancer Oncologist · 2013
    15. A New Classification of Pattern Hair Loss That Is Universal for Men and Women: Basic and Specific (BASP) Classification Journal of The American Academy of Dermatology · 2007

    Related research 10

    1. Effectiveness of the Active Ingredients (Capixyl, Procapil, and Rosemary Extract) of the Trust Tonic for the Treatment of Androgenetic Alopecia in Comparison to Minoxidil Our Dermatology Online · 2022
    2. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    3. A Pilot Split-Scalp Study of Combined Fractional Radiofrequency Microneedling and 5% Topical Minoxidil in Treating Male Pattern Hair Loss Clinical and Experimental Dermatology · 2018
    4. 5% Minoxidil: Treatment for Female Pattern Hair Loss PubMed · 2015
    5. Effectiveness of Once Daily 5% Minoxidil Topical Foam in the Treatment of Women with Thinning Hair Due to Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2015
    6. Understanding and Management of Female Pattern Alopecia Facial Plastic Surgery · 2008
    7. Androgenetic Alopecia in Adolescents PubMed · 2003
    8. Effect of Minoxidil on Hair Growth in Androgenic Alopecia in Women PubMed · 2002
    9. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    10. The Use of Minoxidil to Prevent Alopecia During Chemotherapy for Gynecologic Malignancies PubMed · 1991