Grand Challenges in Dermatologic Drug Discovery: Four Priorities to Transform Skin Disease Treatment

    January 2026 in “ Frontiers in Drug Discovery ”
    Ayman Grada
    Studysummary This study highlights that while advances in dermatology, such as biologics and JAK inhibitors, have improved treatments for conditions like atopic dermatitis and psoriasis, challenges remain, including issues with lasting efficacy and the need for more personalized therapies.
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    Research cited in this study 9

    1. Advances In Cell-Mediated Drug Delivery For Dermatologic Diseases: Mechanisms And Current Applications Pharmaceutics · 2025
    2. JAK1 Gain-Of-Function Variant Causes Alopecia Areata, Atopic Dermatitis, And Autoimmune Thyroid Disease Journal of Allergy and Clinical Immunology · 2025
    3. Skin Structure, Physiology, And Pathology In Topical And Transdermal Drug Delivery Pharmaceutics · 2024
    4. Advances in Microengineered Platforms for Skin Research JID Innovations · 2024
    5. Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment Acta Pharmaceutica Sinica B · 2024
    6. Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments Journal of Investigative Dermatology · 2024
    7. Topical Drug Delivery Strategies for Enhancing Drug Effectiveness by Skin Barriers, Drug Delivery Systems, and Individualized Dosing Frontiers in Pharmacology · 2024
    8. Genome-Wide Meta-Analysis Identifies Novel Loci Conferring Risk of Acne Vulgaris European Journal of Human Genetics · 2023
    9. Innovative Liposomes as a Transfollicular Drug Delivery System: Penetration into Porcine Hair Follicles Journal of Investigative Dermatology · 2006