JAK1 Gain-Of-Function Variant Causes Alopecia Areata, Atopic Dermatitis, And Autoimmune Thyroid Disease

    October 2025 in “ Journal of Allergy and Clinical Immunology ”
    S. Fujita, Shigenori Kabashima, Kumiko Yanagi … Hideaki Morita
    Studysummary A JAK1 variant causes hair loss, skin issues, and thyroid disease, but treatment with a specific inhibitor can help.
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    Research cited in this study 2

    1. Comorbid Bronchial Asthma, Atopic Dermatitis, and Hashimoto's Thyroiditis Are Risk Factors for Early-Onset, Severe, and Prolonged Alopecia Areata Allergy · 2025
    2. JAK Inhibition Decreases the Autoimmune Burden in Down Syndrome eLife · 2024