The Effects of Caffeine and Adenosine on the Microbiome and Lipidome of the Scalp

    May 2025 in “ International Journal of Cosmetic Science ”
    Fengzhu Li, Shu‐Lin Liu, Zhaoying Han … Fang Wang
    Studysummary In this study, researchers found that a shampoo containing caffeine and adenosine significantly altered the scalp microbiome and lipidome in subjects with hair loss over 12 weeks, which may suggest a role for these compounds in enhancing anti-hair loss processes.
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    Research cited in this study 24

    1. Untargeted Hair Lipidomics: Comprehensive Evaluation of the Hair-Specific Lipid Signature and Considerations for Retrospective Analysis Analytical and Bioanalytical Chemistry · 2023
    2. Comparative Analysis of Scalp and Gut Microbiome in Androgenetic Alopecia: A Korean Cross-Sectional Study Frontiers in Microbiology · 2022
    3. Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia Microorganisms · 2021
    4. Scalp Application of the Antioxidant Piroctone Olamine Reduces Hair Shedding in an 8-Week Randomized, Double-Blind, Placebo-Controlled Clinical Study International journal of cosmetic science (Print) · 2021
    5. Finasteride for Hair Loss: A Review Journal of Dermatological Treatment · 2021
    6. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    7. A Scoping Review of Pharmacotherapy, Complementary, and Alternative Medicine, and Surgical Therapies for Androgenic Alopecia Current Dermatology Reports · 2021
    8. Pumpkin Seed Oil vs. Minoxidil 5% Topical Foam for the Treatment of Female Pattern Hair Loss: A Randomized Comparative Trial Journal of Cosmetic Dermatology · 2021
    9. Characteristics of Healthy and Androgenetic Alopecia Scalp Microbiome: Effect of Lindera Strychnifolia Roots Extract as a Natural Solution for Its Modulation International Journal of Cosmetic Science · 2020
    10. The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review PubMed · 2020
    11. New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles British Journal of Dermatology · 2020
    12. Investigation on Microecology of Hair Root Fungi in Androgenetic Alopecia Patients Mycopathologia · 2019
    13. Microbiome in the Hair Follicle of Androgenetic Alopecia Patients PLOS ONE · 2019
    14. Scalp Bacterial Shift in Alopecia Areata PloS one · 2019
    15. Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia PloS one · 2018
    16. Complementary and Alternative Treatments for Alopecia: A Comprehensive Review Skin appendage disorders · 2018
    17. Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells Stem Cell Reports · 2017
    18. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia Skin Pharmacology and Physiology · 2017
    19. Topical Adenosine Increases Thick Hair Ratio in Japanese Men with Androgenetic Alopecia International Journal of Cosmetic Science · 2015
    20. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014
    21. Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial Journal of Dermatology · 2008
    22. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    23. Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro International Journal of Dermatology · 2007
    24. Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001

    Related research 3

    1. Formulation and Evaluation of Herbal Neem Anti-Dandruff Shampoo International journal of Ayurveda and pharma research · 2023
    2. Formulation and Evaluation of Polyherbal Anti-Dandruff Shampoo International journal of Ayurvedic medicine · 2022
    3. A Comparison of Hair Quality and Cosmetic Acceptance Following the Use of Two Anti-Dandruff Shampoos Journal of Investigative Dermatology Symposium Proceedings · 2005