Biologic Therapies and Small-Molecule Inhibitors for Dissecting Cellulitis of the Scalp: A Systematic Review

    April 2026 in “ Dermatology and Therapy ”
    Kevin Díez-Madueño, Belén Argüello-Marcos, Diego Buendia-Castaño … David Saceda-Corralo
    Studysummary This study reviews the efficacy and safety of advanced therapies like TNFα inhibitors and IL-17/IL-23 inhibitors for dissecting cellulitis of the scalp, finding TNFα inhibitors particularly effective for severe or refractory cases, although prospective validation is needed for early intervention benefits.
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    Research cited in this study 9

    1. A Systematic Review of Tumor Necrosis Factor-α Blockers, Anti-Interleukins, and Small Molecule Inhibitors for Dissecting Cellulitis of the Scalp Treatment Orphanet Journal of Rare Diseases · 2025
    2. Dissecting Cellulitis of the Scalp Successfully Treated with a Combination of Ixekizumab and Tofacitinib Journal of Inflammation Research · 2025
    3. Improvement of Recalcitrant Dissecting Cellulitis of the Scalp After a Trial of Upadacitinib Curēus · 2024
    4. Refractory Dissecting Cellulitis of the Scalp Treated With Risankizumab: 2 Case Reports JAAD Case Reports · 2023
    5. Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm Dermatology and therapy · 2023
    6. Perifolliculitis Capitis Abscedens Et Suffodiens Treatment With Tumor Necrosis Factor Inhibitors and Baricitinib: A Case Report and Literature Review Frontiers in medicine · 2023
    7. The role of biologic treatment in special scenarios in hidradenitis suppurativa: Facial and nape phenotype, dissecting cellulitis of the scalp, and lymphedema Dermatologic Therapy · 2021
    8. Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis Drugs in R&D · 2021
    9. Dissecting Cellulitis (Perifolliculitis Capitis Abscedens et Suffodiens): A Comprehensive Review Focusing on New Treatments and Findings of the Last Decade with Commentary Comparing the Therapies and Causes of Dissecting Cellulitis to Hidradenitis Suppurativa Dermatology Online Journal · 2014