Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis

January 2021 in “ Drugs in R&D ”

William Guo, Chencan Zhu, Gregg Stevens, David Silverstein

isotretinoin dissecting cellulitis scarring alopecia acne conglobata hidradenitis suppurativa Accutane

TLDR Isotretinoin is effective for treating dissecting cellulitis, but recurrence is common.

The review and meta-analysis assessed the efficacy of isotretinoin in treating dissecting cellulitis of the scalp, a primary scarring alopecia. Five multi-patient studies were included, and the pooled meta-analysis showed an overall efficacy rate of 0.9 (95% CI: 0.81–0.97) with a sensitivity analysis range of 0.83–0.94. Recurrence occurred in 24% of patients. Common associated diseases included acne conglobata (20%) and hidradenitis suppurativa (19%). The study concluded that isotretinoin was effective in improving symptoms, though recurrence was common.

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Chinese patients with primary cicatricial alopecia often have folliculitis decalvans, benefit from treatment, but may experience relapse, with dermoscopy being a useful diagnostic tool.

research Primary Cicatricial Alopecias: Clinicopathology of 112 Cases

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