Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis

    January 2021 in “ Drugs in R&D ”
    William Guo, Chencan Zhu, Gregg Stevens, David Silverstein
    Image of study
    TLDR Isotretinoin is effective for treating dissecting cellulitis, but recurrence is common.
    The review and meta-analysis assessed the efficacy of isotretinoin in treating dissecting cellulitis of the scalp, a primary scarring alopecia. Five multi-patient studies were included, and the pooled meta-analysis showed an overall efficacy rate of 0.9 (95% CI: 0.81–0.97) with a sensitivity analysis range of 0.83–0.94. Recurrence occurred in 24% of patients. Common associated diseases included acne conglobata (20%) and hidradenitis suppurativa (19%). The study concluded that isotretinoin was effective in improving symptoms, though recurrence was common.
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      in Product  2 upvotes 1 month ago
      Isotretinoin and tretinoin are different; isotretinoin can cause hair loss and has more side effects. Tretinoin may affect minoxidil absorption, and users suggest waiting before applying minoxidil.

      community Which retinoid for better min absorption?

      in Product  4 upvotes 3 months ago
      User is on vacation in Greece and wants to buy tretinoin or isotretinoin to improve Minoxidil absorption. They are considering isotretinoin since it is available over-the-counter in Greece but requires a prescription back home.

      community Dut/Minox/Needling to Dut/Oral Minox/Tretinoin/Needling

      in Minoxidil  3 upvotes 7 months ago
      The user had been using Minoxidil and Dutasteride with micro-needling but experienced hair loss after switching Minoxidil brands. Their doctor prescribed oral Minoxidil and Tretinoin, but the pharmacist suggested isotretinoin might be a more cost-effective alternative.

      community Seborrheic dermatitis - can it cause long-term shedding (or telogen effluvium)?

      in Advice  6 upvotes 4 years ago
      A user is experiencing significant hair loss and scalp issues despite using Minoxidil, finasteride, and RU58841 since 2017. They switched to oral Minoxidil and are now on isotretinoin and topical corticosteroids for seborrheic dermatitis but continue to lose hair and seek advice on whether inflammation or treatment changes are the cause.

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