Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross-Sectional Observational Study

    November 2025 in “ Journal of Cosmetic Dermatology ”
    Suparuj Lueangarun, Patrick Po‐Han Huang, Wan‐Yi Chou … Daniela Lemes
    Studysummary This study found that exosome-based therapy using rose stem cell-derived exosomes may safely induce hair repigmentation in individuals with gray hair, particularly for those with shorter durations of graying and androgenetic alopecia.
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    Research cited in this study 14

    1. Achieving Sustained Hair Repigmentation in Poliosis Circumscripta: Retreatment Outcomes Using Exosomes and Fractional Picosecond Laser Journal of Cosmetic Dermatology · 2025
    2. The Efficacy of Adipose Stem Cell-Derived Exosomes in Hair Regeneration Based on a Preclinical and Clinical Study International Journal of Dermatology · 2024
    3. The Roles of Exosomes in Regulating Hair Follicle Growth Clinical Cosmetic and Investigational Dermatology · 2024
    4. Hair Repigmentation of Poliosis Circumscripta in Androgenetic Alopecia Patient Treated With Exosomes and Fractional Picosecond Laser Journal of Cosmetic Dermatology · 2024
    5. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    6. Human Hair Graying Revisited: Principles, Misconceptions, And Key Research Frontiers Journal of Investigative Dermatology · 2023
    7. Exosomes for Hair Growth and Regeneration Journal of Bioscience and Bioengineering · 2023
    8. Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress International journal of biological sciences · 2023
    9. Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle Stem Cell Research & Therapy · 2021
    10. Histopathology of Aging of the Hair Follicle Journal of Cutaneous Pathology · 2019
    11. Aging in Hair Follicle Stem Cells and Niche Microenvironment The Journal of Dermatology · 2017
    12. Premature Hair Whitening Is an Independent Predictor of Carotid Intima-Media Thickness in Young and Middle-Aged Men Internal Medicine · 2013
    13. Stem Cell Factor/c-Kit Signaling in Normal and Androgenetic Alopecia Hair Follicles Journal of Endocrinology · 2008
    14. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998