Alopecia Due to Chemotherapeutics, Hedgehog Inhibitors, Targeted Antibody Therapies, and Immune Checkpoint Inhibitors

    May 2024 in “ Deleted Journal ”
    Michael Max Sachse, Katharina C. Kähler
    Studysummary This study reports that chemotherapy-induced hair loss affects up to 65% of patients, typically within 1 to 3 weeks of treatment, while scalp cooling may help prevent severe hair loss with taxane-based therapies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 15

    1. Low-Intensity Ultrasound as a Potential Intervention Strategy to Protect Human Scalp Hair Follicles from Taxane-Induced Toxicity Journal of Investigative Dermatology · 2023
    2. Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming? Current Oncology · 2023
    3. Peroxisome Proliferator-Activated Receptor-γ Signalling Protects Hair Follicle Stem Cells from Chemotherapy-Induced Apoptosis and Epithelial-Mesenchymal Transition British journal of dermatology/British journal of dermatology, Supplement · 2021
    4. Prevention and Treatment of Chemotherapy-Induced Alopecia Dermatology practical & conceptual · 2020
    5. CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia EMBO Molecular Medicine · 2019
    6. Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails American Journal of Clinical Dermatology · 2018
    7. Cutaneous Toxicity as a Predictive Biomarker for Clinical Outcome in Patients Receiving Anticancer Therapy Journal of the American Academy of Dermatology · 2018
    8. From Basal Cell Carcinoma Morphogenesis to Alopecia Induced by Hedgehog Inhibitors: Connecting the Dots British Journal of Dermatology · 2017
    9. Immune-Related Alopecia (Areata and Universalis) in Cancer Patients Receiving Immune Checkpoint Inhibitors British journal of dermatology/British journal of dermatology, Supplement · 2016
    10. Alopecia in Patients Treated with Molecularly Targeted Anticancer Therapies Annals of Oncology · 2015
    11. RASopathic Alopecia: Hair Changes Associated with Vemurafenib Therapy Journal of The American Academy of Dermatology · 2015
    12. Efficacy of Interventions for Prevention of Chemotherapy-Induced Alopecia: A Systematic Review and Meta-Analysis International journal of cancer · 2014
    13. Analysis of Quantitative Changes in Hair Growth During Treatment With Chemotherapy or Tamoxifen in Patients With Breast Cancer: A Cohort Study British Journal of Dermatology · 2013
    14. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    15. The Biology of Hair Follicles The New England Journal of Medicine · 1999