Expert Perspectives: Evidence-Based Applications of Polynucleotides in Aesthetic Medicine and Dermatology

    January 2026 in “ Clinical Cosmetic and Investigational Dermatology ”
    NARK-KYOUNG RHO, Suneel Chilukuri, Gavin Chan … Atchima Suwanchinda
    Studysummary This expert opinion article presents insights from dermatologists and aesthetic physicians on using polynucleotides (Rejuran®) for skin hydration, rejuvenation, structural support, barrier repair, and scar remodeling, noting their favorable safety profile but highlighting the need for more robust evidence and research.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 5

    1. Polynucleotides Versus Platelet-Rich Plasma for Androgenetic Alopecia: A Case Series JOJ Dermatology & Cosmetics · 2025
    2. Polynucleotides as a Novel Therapeutic Approach in Androgenetic Alopecia: An Analysis of Effectiveness and Safety Archives of Dermatological Research · 2025
    3. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review Journal of Cosmetic Dermatology · 2024
    4. Injectable Skin Boosters in Aging Skin Rejuvenation: A Current Overview Archives of Plastic Surgery · 2024
    5. Consensus Report on the Use of PN-HPT (Polynucleotides Highly Purified Technology) in Aesthetic Medicine Journal of cosmetic dermatology · 2020