Investigation of the Role of SIRT3, SIRT7, NFATC1, and PDL-1 Genes in Androgenetic Alopecia

    November 2024 in “ BMC Research Notes
    Hadis Abbasian, Mehrdad Noruzinia, Masoud Garshasbi
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    TLDR SIRT3 and SIRT7 genes may play a role in hair loss.
    This study examines the expression of SIRT3, SIRT7, NFATC1, and PDL-1 genes in androgenetic alopecia (AGA) using mesenchymal stem cells from six men. It found that SIRT3 and SIRT7, which decrease during hair follicle aging, were reduced in AGA samples, suggesting their involvement in AGA development. NFATC1 and PDL-1 were elevated, though their roles need further investigation. The study highlights the potential link between these genes and AGA, noting the importance of mitochondrial function and stem cell activity. However, the small sample size limits the findings, and larger studies are needed to explore these genes as therapeutic targets.
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