Investigations of 13 Genes in Non-Cicatricial Alopecia

August 2023

Mariana Păun, Gustavo Torres, George Sorin Țiplica, V. Cauni

androgenetic alopecia alopecia areata single nucleotide polymorphisms GR-alpha gene GPR44-2 gene SULT1A1 gene CRABP2 gene minoxidil SRD5A1 PTGFR-2 Dutasteride Latanoprost DNA analysis AGA AA SNPs Rogaine Propecia

TLDR DNA analysis can help tailor alopecia treatment.

The study investigated the association between androgenetic alopecia (AGA) and alopecia areata (AA) and 45 tag single nucleotide polymorphisms (SNPs) of 13 genes in 287 Romanian and 882 Brazilian patients. The DNA samples were extracted from saliva using the qPCR technique. The results showed that the GR-alpha gene, GPR44-2 gene, SULT1A1 gene, and CRABP2 gene were statistically significantly different in Brazil compared to Romania. Minoxidil may be recommended in half of the cases of AGA and AA. Patients with AGA and high expression of SRD5A1 or PTGFR-2 may benefit from Dutasteride, respectively Latanoprost treatment. Most of the studied genes showed no differences between the two populations. The study concluded that DNA analysis of patients with alopecia may contribute to successful treatment.

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