Process Validation of Beta-Sitosterol Hair Gel Formulation and Evaluation of 5 Alpha Reductase Inhibition In Vitro for the Treatment of Androgenetic Alopecia

March 2023 in “ International Journal of Applied Pharmaceutics ”

ARPAN CHAKRABORTY, Arka Bhattacharjee, MANAS CHAKRABORTY, GOUTAM MUKHOPADHYAY

beta-sitosterol 5 alpha reductase inhibition androgenetic alopecia carbopol 940 finasteride in vitro antiandrogenic β-sitosterol 5α-reductase inhibition androgenic alopecia Propecia

Studysummary In this study, researchers formulated a topical gel containing β-sitosterol for alopecia treatment and found it demonstrated good 5 alpha reductase inhibitory activity in vitro, comparable to a commercial product, indicating its potential for further antiandrogenic activity investigation.

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This study reports that using molecular docking methods, beta-sitosterol and stigmasterol from Serenoa repens were identified as potential natural inhibitors of the 5AR1 enzyme, which could serve as novel treatments for androgenetic alopecia based on their inhibitory action observed in a laboratory setting.

research Improvement of Alopecia and Decreases in Hair Cortisol and Dihydrotestosterone Concentrations After the Topical Use of Plant Extracts in Men With Androgenetic Alopecia

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This study found that phyto-vesicles of ß-sitosterol showed better absorption and improved activity for treating androgenetic alopecia in rats compared to the compound and its complex.

research Hair Growth Promoting Activity of Eclipta Alba in Male Albino Rats

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A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

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This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

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