Influencing Hair Regrowth With EGCG by Targeting Glycogen Synthase Kinase-3β Activity: A Molecular Dynamics Study

    February 2025 in “ Journal of Receptors and Signal Transduction ”
    Hamid Raza Moqaddasi, Anshul Singh, Shoma Mukherjee … Sandeep Kumar
    Studysummary In this study, computational analysis identified EGCG as the most effective GSK3β inhibitor among tested compounds, suggesting its potential for promoting hair regrowth by interacting with signaling pathways related to hair follicle cycling, although further experimental testing is needed.
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    Research cited in this study 8

    1. Water Extract of Cacumen Platycladi Promotes Hair Growth Through the Akt/GSK3β/β-Catenin Signaling Pathway Frontiers in Pharmacology · 2023
    2. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    3. The Promoting Effect of Rumex Japonicas Houttuyn Ethanol Extract on Hair Growth Daehanhanuihakoeji · 2020
    4. Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation British Journal of Dermatology · 2019
    5. Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid Aging · 2019
    6. LncRNA PlncRNA-1 Regulates Proliferation and Differentiation of Hair Follicle Stem Cells Through TGF-β1-Mediated Wnt/β-Catenin Signal Pathway Molecular Medicine Reports · 2017
    7. Human Placental Extract Exerts Hair Growth-Promoting Effects Through the GSK-3β Signaling Pathway in Human Dermal Papilla Cells International Journal of Molecular Medicine · 2015
    8. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005