Risks And Side Effects In The Medical Management Of Benign Prostatic Hyperplasia

December 2023 in “ Prostate International ”

Abdulghafour Halawani, Ryan F. Paterson, Tianshuang Zhong, Katie Du, Runhan Ren, Connor M. Forbes

benign prostatic hyperplasia alpha-blockers phosphodiesterase-5 inhibitors 5-alpha-reductase inhibitors ejaculatory dysfunction gynecomastia metabolic syndrome saw palmetto BPH PDE5-Is 5ARIs

Studysummary This review provides an overview of the risks and side effects associated with common medications used to treat benign prostatic hyperplasia, highlighting the importance for clinicians and patients to discuss these aspects for informed decision-making.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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Suspected Adverse Reactions to Medications and Food Supplements Containing Serenoa Repens: A Worldwide Analysis of Pharmacovigilance and Phytovigilance Spontaneous Reports

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This meta-analysis reports that male sex, hypertension, tamsulosin, finasteride, benzodiazepines, and antipsychotics are significantly associated with increased risk of developing intraoperative floppy-iris syndrome during cataract surgery.

research The Role of Benign Prostatic Hyperplasia Treatments in Ejaculatory Dysfunction

8 citations , August 2021 in “Fertility and Sterility”

This review discusses the potential risks of ejaculatory dysfunction associated with both medical and surgical treatments for lower urinary tract symptoms due to benign prostatic hyperplasia and their implications for male fertility, but it reports no new clinical results.

research Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride

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This pharmacovigilance study found an increased association of suicidality and psychological adverse events with finasteride use, especially among younger patients using it for alopecia.

research Incidence of Type 2 Diabetes Mellitus in Men Receiving Steroid 5α-Reductase Inhibitors: Population-Based Cohort Study

29 citations , April 2019 in “BMJ. British medical journal”

This study concluded that men with benign prostatic hyperplasia receiving steroid 5α-reductase inhibitors, such as dutasteride or finasteride, have a higher risk of developing new onset type 2 diabetes compared to those taking tamsulosin.

research Association of Suicidality and Depression With 5α-Reductase Inhibitors

90 citations , March 2017 in “JAMA Internal Medicine”

In this study, older men using 5α-reductase inhibitors for prostatic enlargement did not show increased risk of suicide, but had elevated risks of self-harm and depression.

research Adverse Effects and Safety of 5-Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review

32 citations , July 2016 in “PubMed”

This review discusses the adverse events associated with 5-alpha reductase inhibitors, finding them generally well-tolerated but noting potential risks like sexual side effects and psychological effects in men, and sparse data on use in women.

research Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know?

111 citations , August 2015 in “Reviews in Endocrine and Metabolic Disorders”

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research Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study

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research Male Breast Cancer and 5α-Reductase Inhibitors Finasteride and Dutasteride

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research Acute Liver Damage Due to Serenoa Repens: A Case Report

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research 5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection

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research Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders

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research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations , December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

research Finasteride for Female Androgenetic Alopecia

51 citations , October 2002 in “British Journal of Dermatology”

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

1054 citations , February 1998 in “The New England Journal of Medicine”

In this study, men with benign prostatic hyperplasia who took finasteride for four years experienced reduced urinary symptoms, fewer surgeries, less acute urinary retention, increased urinary flow rates, and decreased prostate volume.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations , October 1992 in “The New England Journal of Medicine”

In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.