Vitamin D Receptor Cross-Talk With P63 Signaling Promotes Epidermal Cell Fate
June 2023
in “
Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology
”
Vitamin D receptor VDR p63 signaling epidermal cell fate stem cell activation skin wounding hair follicles stem cell loss cell differentiation cell migration interfollicular epidermis super-enhancer epidermal master regulator p63 skin cells stem cells skin injury hair roots cell loss cell growth cell movement skin surface enhancer skin regulator
Studysummary This study found that deleting the vitamin D receptor from specific stem cells in mouse hair follicles disrupts their ability to regenerate the epidermis after injury, suggesting an essential interaction with the transcription factor p63.
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