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    Vitamin D Receptor Cross-Talk With P63 Signaling Promotes Epidermal Cell Fate

    Yuko Oda, Candance Wong, Dennis H. Oh … Daniel D. Bikle
    Studysummary This study found that deleting the vitamin D receptor from specific stem cells in mouse hair follicles disrupts their ability to regenerate the epidermis after injury, suggesting an essential interaction with the transcription factor p63.
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    Research cited in this study 10

    1. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    2. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    3. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-Epithelialization Endocrinology · 2017
    4. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    5. Lineage Analysis of Epidermal Stem Cells Cold Spring Harbor Perspectives in Medicine · 2014
    6. Reciprocal Role of Vitamin D Receptor on β-Catenin Regulated Keratinocyte Proliferation and Differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013
    7. Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche Nature Reviews Molecular Cell Biology · 2013
    8. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    9. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    10. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008

    Related research 1

    1. Development of Pigmented Reconstructed Human Epidermis Model Containing Human Melanoblasts from Keratinocyte Culture Journal of Investigative Dermatology · 2019