FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice

    November 2004 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Lars Mecklenburg, Ralf Paus, Zdeněk Halata … John P. Sundberg
    Studysummary This study found that mutations in the Foxn1 gene in nude mice affect not only hair but also nail structure and differentiation, offering insights into nail hypergranulosis pathogenesis relevant to human nail diseases.
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    Research cited in this study 9

    1. Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    2. Formation of Regulator/Target Gene Relationships During Evolution Gene · 2000
    3. Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype Developmental Dynamics · 2000
    4. Keratin Expression in the Normal Nail Unit: Markers of Regional Differentiation British Journal of Dermatology · 2000
    5. Genetically Separable Determinants of Hair Keratin Gene Expression Developmental Dynamics · 2000
    6. Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation Mechanisms of Development · 1999
    7. Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia Developmental biology · 1999
    8. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998
    9. Cutaneous Ultrastructural Features of the Flaky Skin (Fsn) Mouse Mutation The Journal of Dermatology · 1995