The Efficacy and Safety of Oral Spironolactone in the Treatment of Female Pattern Hair Loss: A Systematic Review and Meta-Analysis

    August 2023 in “ Cureus ”
    Majed Aleissa
    Studysummary In a systematic review and meta-analysis, this study reported that oral spironolactone showed a 56.60% overall improvement in female pattern hair loss, with better results in combination therapy, but emphasized the need for more research due to varied treatment responses and adverse event rates.
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    Research cited in this study 12

    1. The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2023
    2. Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: A Prospective, Single-Center, Parallel-Group, Evaluator-Blinded, Randomized Trial Frontiers in Medicine · 2022
    3. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    4. Psychology of Hair Loss Patients and Importance of Counseling Indian Journal of Plastic Surgery · 2021
    5. Combination Oral Minoxidil and Spironolactone for the Treatment of Androgenetic Alopecia in Adolescent Girls Journal of The American Academy of Dermatology · 2020
    6. Spironolactone for Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2020
    7. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    8. Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy Journal of The American Academy of Dermatology · 2015
    9. Androgenetic Alopecia: Quality of Life and Associated Lifestyle Patterns International Journal of Trichology · 2010
    10. Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil Australasian Journal of Dermatology · 2007
    11. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
    12. Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2001

    Related research 5

    1. Spironolactone in Dermatology: Uses in Acne, Hidradenitis Suppurativa, Female Pattern Hair Loss, and Hirsutism Actas Dermo-Sifiliográficas · 2020
    2. Azathioprine for the Treatment of Extensive Forms of Alopecia Areata: A Systematic Review Acta Medica Philippina · 2019
    3. 5α-Reductase Inhibitors in Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2014
    4. Weight Gain and Hair Loss During Anti-TNF Therapy International Journal of Rheumatology · 2012
    5. Is Topical Minoxidil Solution Effective on Androgenetic Alopecia in Routine Daily Practice? Journal of Dermatological Treatment · 2007