CD34 Defines Melanocyte Stem Cell Subpopulations With Distinct Regenerative Properties

April 2019 in “ PLOS genetics ”

Sandeep S. Joshi, Bishal Tandukar, Pan Li, Jennifer M. Huang, Ferenc Livák, Barbara J. Smith, Theresa K Hodges, Anup Mahurkar, Thomas J. Hornyak

CD34 melanocyte stem cells McSCs bulge region hair follicles neural crest stem cell marker neural differentiation myelination secondary hair germ SHG melanogenic gene expression melanocyte differentiation hair follicle pigmentation alopecia pigmentation disorders

Studysummary This study found that CD34- melanocyte stem cells regenerated pigmentation more efficiently, while CD34+ cells showed potential for neuron myelination, suggesting different therapeutic applications for each population.

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