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    The Role of Reactive Oxygen Species in the Pathogenesis of Alopecia Areata: A Systematic Review and Meta-Analysis

    January 2025 in “ Skin Pharmacology and Physiology ”
    Jonah Perlmutter, Polycronis P. Akouris, S. Frémont … Marni Wiseman
    Studysummary This study found that alopecia areata patients have elevated oxidative stress markers, such as OSI and MDA, and reduced antioxidant enzyme activities, suggesting a significant role for oxidative stress in the disease and potential value in targeting it therapeutically.
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    Research cited in this study 10

    1. Oxidative Stress and Antioxidant Markers in Patients with Alopecia Areata: A Comparative Cross-Sectional Study Indian journal of dermatology, venereology, and leprology · 2022
    2. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    3. Ischemia-Modified Albumin as a New Biomarker in Predicting Oxidative Stress in Alopecia Areata Turkish journal of medical sciences · 2019
    4. Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata Skin pharmacology and physiology · 2018
    5. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    6. The Role of Micronutrients in Alopecia Areata: A Review American Journal of Clinical Dermatology · 2017
    7. Investigation of Oxidative Stress in Patients with Alopecia Areata and Its Relationship with Disease Severity, Duration, Recurrence, and Pattern Clinical and experimental dermatology · 2014
    8. Oxidative Stress in Alopecia Areata: A Case-Control Study American Journal of Clinical Dermatology · 2013
    9. Assessment of Zinc and Copper Contents in Scalp Hair and Serum and Superoxide Dismutase, Glutathione Peroxidase, and Malondialdehyde in Serum of Androgenetic Alopecia and Alopecia Areata Patients Medical journal of Tabriz University of Medical Sciences and Health Services · 2011
    10. Effect of Nutrient Antioxidants on Oxidative Stress Indicators in Patients with Alopecia Areata Almustansiriya journal of pharmaceutical sciences/˜Al-œMustansiriyah journal of pharmaceutical sciences · 2007