Ancient Lineages of the Keratin-Associated Protein (KRTAP) Genes and Their Co-option in the Evolution of the Hair Follicle

    November 2022 in “ Research Square (Research Square) ”
    Thomas Litman, Wilfred D. Stein

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that keratin-associated proteins related to metallothionein and occludin appear in various animals, suggesting they may have roles beyond hair characteristics and were later adapted for hair production.
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    Research cited in this study 7

    1. Identification of Key Genes and Signaling Pathways Related to Hetian Sheep Wool Density by RNA-Seq Technology PLOS ONE · 2022
    2. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
    3. Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression PloS one · 2016
    4. Mammalian Keratin-Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments BMC genomics · 2014
    5. Krtap11-1, A Hair Keratin-Associated Protein, As A Possible Crucial Element For The Physical Properties Of Hair Shafts Journal of Dermatological Science · 2014
    6. Bidirectional Binding Property of High Glycine–Tyrosine Keratin-Associated Protein Contributes to the Mechanical Strength and Shape of Hair Journal of structural biology · 2013
    7. Molecular Evolution of the Keratin Associated Protein Gene Family in Mammals: Role in the Evolution of Mammalian Hair BMC Evolutionary Biology · 2008