June 202126
In a randomized trial, the ALRV5XR oral-plus-topical regimen in women raised terminal hair density about 20% at 24 weeks. Adding a SULT1A1 booster to topical minoxidil yielded regrowth in 75% of men versus 33% with placebo adjuvant in a randomized trial. In a prospective study, twice-weekly blue LED light increased hair density and shaft width in 90% of androgenetic alopecia patients. A case-control study found men with androgenetic alopecia had higher homocysteine and MTHFR-related coronary risk, with cardiac evaluation suggested. For alopecia areata, oral baricitinib 4 mg brought 52% of adults to SALT ≤20 at week 36 versus 3.6% on placebo.
- Safety and efficacy of ALRV5XR in women with androgenetic alopecia or telogen effluvium: A randomised, double-blinded, placebo-controlled clinical trial In a 46-woman randomized trial, the ALRV5XR oral-plus-topical regimen raised terminal hair density about 20% at 24 weeks, with no adverse events reported.
- SULT1A1 (Minoxidil Sulfotransferase) enzyme booster significantly improves response to topical minoxidil for hair regrowth In a 24-man randomized trial, adding a SULT1A1 enzyme booster to 5% minoxidil yielded regrowth in 75% versus 33% with placebo adjuvant over 60 days.
- The new regenerative and innovative strategies in hair loss A review of regenerative and innovative strategies, including PRP and the ALRV5XR compound, for male and female pattern hair loss.
- MTHFR C677T Polymorphism and Serum Homocysteine Level as Risk Factors of Coronary Heart Disease in Patients with Androgenetic Alopecia: A Case Control Study In a case-control study, men with androgenetic alopecia had higher homocysteine and MTHFR-related coronary risk; cardiac evaluation is suggested.
- Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study In a phase 2 randomized trial, 52% of adults with severe alopecia areata on baricitinib 4 mg reached SALT ≤20 at week 36 versus 3.6% on placebo.
- Blue light-emitting diodes in hair regrowth: the first prospective study In 20 androgenetic alopecia patients, twice-weekly blue LED light for 10 weeks increased hair density and shaft width in 90% of patients.
- A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata A literature review examines the role, efficacy, and safety of JAK inhibitors as a treatment for alopecia areata.
- Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration In mice, adipose stem cell exosomes increased regenerated hairs and follicles versus control grafts.
- Use of hair products in relation to ovarian cancer risk In a 40,559-woman cohort, frequent hair straightener use was linked to doubled ovarian cancer risk; dyes showed mixed associations by tumor type.
- Psychology’s medicalization of male baldness A review of 37 psychosocial studies found most male baldness impact research had commercial influence and disease framing.
- Change in hair growth-related gene expression profile in human isolated hair follicles induced by 5-alpha reductase inhibitors – dutasteride and finasteride – in the presence of testosterone An ex vivo study examined how dutasteride and finasteride alter hair-growth gene expression in plucked human follicles.
- Regulatory Effect of Cannabidiol (CBD) on Decreased β-Catenin Expression in Alopecia Models by Testosterone and PMA Treatment in Dermal Papilla Cells In dermal papilla cells, CBD pretreatment restored β-catenin expression suppressed by testosterone or PMA, suggesting a possible anti-alopecia mechanism.
- Hair Growth Promotion by δ-Opioid Receptor Activation In mice and hair organ cultures, delta-opioid receptor agonist UFP-512 accelerated anagen and lengthened hair via Wnt/β-catenin.
- Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion In mice, fisetin prompted keratinocyte exosome release that activated hair follicle stem cells and promoted hair growth.
- Alterations of collagen type 1, skin fibroblasts, and macrophages in the scalp following the treatment of 1550‐nm erbium glass fractional laser for androgenetic alopecia a study of collagen, fibroblast, and macrophage changes in scalp after 1550-nm fractional laser treatment for androgenetic alopecia.
- Clinical efficacy of adipocyte-derived stem cells conditioned media combined with micro-injury in refractory patch of alopecia areata In 14 patients with refractory alopecia areata patches, stem-cell conditioned media plus laser or microneedling gave over 50% regrowth in 64%.
- TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cell on Hair Follicle Regeneration In mice, bone marrow stem cell injections shifted follicles to anagen and identified candidate proteins driving regeneration.
- Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)* An international consensus group produced standardized diagnostic criteria and outcome measures for frontal fibrosing alopecia clinical trials.
- The impact of exogenous vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and early-onset androgenic alopecia In men with autoimmune thyroiditis, vitamin D lowered thyroid antibodies less in those with early-onset androgenetic alopecia; no hair outcomes studied.
- Quality of life measurement in alopecia areata. Position statement of the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes A European dermatology task force recommends DLQI, Scalpdex, and AA-specific instruments for measuring quality of life in alopecia areata.
- Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway In human dermal papilla spheres, ginsenoside Rg4 enhanced hair-inductive properties via the AKT/GSK-3β/β-catenin pathway.
- Application of Ethanol Extracts From Alnus sibirica Fisch. ex Turcz in Hair Growth Promotion In cell studies, Alnus sibirica extract and oregonin showed antioxidant and anti-apoptotic effects and reduced DHT production in dermal papilla cells.
- Development and initial validation of a modified Sinclair scale for female pattern hair loss in men development and initial validation of a modified Sinclair scale for female pattern hair loss in men.
- Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing In skin models, polymeric micelles delivered spironolactone preferentially to pilosebaceous units, aimed at wound healing and androgen-related skin disease.
- Long-Term Utility of Follicular Unit Excision in Lichen Planopilaris—Correlation of Graft Survival With Histopathological and Ultrasound Biomicroscopic Parameters In 32 inactive lichen planopilaris patients, transplanted graft survival was about 79% at 24 months with no reactivation observed.
- [Bimatoprost promotes hair growth of reconstructed hair follicles in mice through activation of the Wnt/β-catenin signaling pathway]. In mice with reconstructed hair follicles, topical bimatoprost grew longer hair than saline, comparable to minoxidil, via Wnt/β-catenin activation.