August 202128
Autologous fat-derived SVF injections were found to increase hair density in pattern hair loss, and non-ablative Er:YAG laser was reported to improve hair quality in most treated patients. 5-aminolevulinic acid photodynamic therapy showed no hair growth benefit, while piroctone olamine scalp products reduced shedding in women with thinning. A separate antioxidant shampoo regimen also reduced shedding while increasing hair count. Robotic recipient site preparation was reported consistent for hair transplant surgery, and severe early-onset pattern hair loss was associated with coronary artery disease. An alopecia areata review concluded standard treatments have limited efficacy, with JAK inhibitors among emerging options.
- Innovative method of alopecia treatment by autologous adipose-derived SVF In patients with pattern hair loss, a single scalp injection of autologous fat-derived stromal vascular fraction significantly increased hair density at 3 and 6 months versus untreated scalp.
- Non‐ablative Er:YAG laser is an effective tool in the treatment arsenal of androgenetic alopecia In 16 patients with pattern hair loss, non-ablative Er:YAG laser, alone or with PRP or minoxidil, improved hair quality in 93% with no adverse reactions reported.
- Sublingual minoxidil for the treatment of male and female pattern hair loss: a randomized, double‐blind, placebo‐controlled, phase 1B clinical trial a randomized, double-blind, placebo-controlled phase 1B trial of sublingual minoxidil for male and female pattern hair loss.
- Treatment of androgenetic alopecia with 5-aminolevulinic acid photodynamic therapy: A randomized, placebo-controlled, split-scalp study of efficacy and safety In a 7-patient split-scalp randomized trial, six sessions of 5% ALA photodynamic therapy did not increase hair growth in pattern hair loss, with only mild edema and pain.
- Lasers, lights, and compounds for hair loss in aesthetics A review of lasers, lights and compounds for hair loss, covering topical and oral agents, PRP, low-level laser therapy and debates including post-finasteride syndrome.
- Efficacy and safety profile of oral spironolactone use for androgenic alopecia: A systematic review. a systematic review of the efficacy and safety of oral spironolactone for androgenic alopecia.
- Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8‐week randomized, double‐blind, placebo‐controlled clinical study In an 8-week placebo-controlled trial, piroctone olamine shampoo or leave-on reduced shedding and increased hair amount in women with self-perceived thinning.
- Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24‐week randomized, double‐blind, placebo‐controlled clinical trial In a 24-week placebo-controlled trial, an antioxidant shampoo and leave-on regimen reduced shedding and increased total hair count in people with self-perceived thinning.
- Robotically Assisted Recipient Site Preparation in Hair Restoration Surgery In 31 men with pattern hair loss, robotic recipient site creation for hair transplant was fast, safe and consistent, with crusting the most common complication and high satisfaction.
- Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management A review updates alopecia areata causes and management, noting limited efficacy of standard treatments and emerging options like JAK inhibitors, biologics, and PRP.
- Association Between Androgenic Alopecia and Coronary Artery Disease: A Cross-Sectional Study of Han Chinese Male Population In a cross-sectional study of Han Chinese men, severe and early-onset pattern hair loss were independently associated with coronary artery disease and atherosclerosis severity.
- Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle Human dermal gamma-delta T cells attacked stressed hair follicles ex vivo, triggering alopecia areata-like immune privilege collapse and catagen.
- Frontal Fibrosing Alopecia – a review and a practical guide for clinicians A review and practical guide to frontal fibrosing alopecia, where 5-alpha-reductase inhibitors, intralesional steroids and hydroxychloroquine have the highest evidence for treatment.
- Hair growth-promotion effects at the cellular level and antioxidant activity of the plant-based extract Phyllotex™ In cell studies, the herbal formulation Phyllotex stimulated dermal papilla cell proliferation, suppressed TGF-beta1 and protected against oxidative stress, suggesting hair growth potential.
- Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth A review of how sympathetic nerves and norepinephrine regulate hair follicle growth and hair follicle stem cells.
- Biological activity and hair inducing function of biomimetic dermal papilla spheres prepared by hanging drops of methacrylate gelatin Gelatin-based biomimetic dermal papilla spheres partly restored the hair-inducing ability of high-passage mouse dermal papilla cells in nude mice.
- Clinical effects of follicle unit extraction and transplantation combined with topical recombinant bovine basic fibroblast growth factor and minoxidil in the treatment of secondary cicatricial alopecia In cicatricial alopecia, FUE transplantation combined with bFGF and minoxidil improved graft survival and satisfaction and reduced hair loss versus FUE alone.
- Clinicopathological characteristics and treatment outcomes of fibrosing alopecia in a pattern distribution: A retrospective cohort study In 24 women with fibrosing alopecia in a pattern distribution, treatment arrested progression in 14 and regrew hair in 2, with better outcomes when started early.
- Topical finasteride dose evaluation for treatment of androgenetic alopecia using computer simulations Computer simulations predicted very low plasma finasteride levels from topical 0.1–1% scalp solutions, supporting topical finasteride as a potential pattern hair loss treatment.
- Cholesterol and Phospholipid-free Multilamellar Niosomes Regulate Transdermal Permeation of a Hydrophobic Agent Potentially Administrated for Treating Diseases in Deep Hair Follicles Multilamellar niosomes penetrated deep into hair follicles in vitro, a potential transdermal delivery route for follicle-targeted drugs.
- Exercise in dermatology: Exercise’s influence on skin aging, skin cancer, psoriasis, venous ulcers, and androgenetic alopecia a review of how exercise influences skin aging, skin cancer, psoriasis, venous ulcers and androgenetic alopecia.
- Classification Framework for Healthy Hairs and Alopecia Areata: A Machine Learning (ML) Approach A machine learning model classified alopecia areata versus healthy hair images with up to 91.4% accuracy using support vector machines.
- Evaluation of Susceptibility Genes/Loci Associated with Male Androgenetic Alopecia (MAGA) for Female-Pattern Hair Loss in a Chinese Han Population and a Brief Literature Review In a Chinese Han population, 22 male-pattern hair loss gene loci showed no association with female-pattern hair loss, suggesting the two are etiologically separate.
- A systematic summary of survival and death signalling during the life of hair follicle stem cells A review of survival and death signalling in hair follicle stem cells and the pathways that could be targeted for hair loss therapy.
- Cannabinoids for skin diseases and hair regrowth A review finds cannabinoids, including CBD for hair growth, are promising but dermatologists should be cautious given insufficient clinical efficacy and safety data.
- Urban‐rural differences in the prevalence of female pattern hair loss among secondary school girls: A cross‐sectional study In a cross-sectional study, 28.6% of secondary school girls had female pattern hair loss, more common in rural areas and linked to irregular menses, thyroid disease and hirsutism.
- The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function In mice, the anti-apoptotic protein Bcl-2 is required to maintain hair follicle bulge stem cells, and its loss disrupts cyclic hair regeneration.
- Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures Human iPS cell-derived dermal papilla substitutes assembled with keratinocytes in vitro mimicked hair follicle structures and gene expression.