April 202136
Topical cetirizine 1% increased hair density in male pattern hair loss, though minoxidil 5% proved superior. Topical CBD-rich hemp oil was reported to raise hair counts by 93.5% in an uncontrolled series. Evaluation before PRP revealed hidden scarring alopecia requiring immunomodulatory treatment instead. Intradermal QR678Neo injections were found more effective than derma-roller delivery, which was less painful. Modern follicular-unit transplantation outlined surgical candidates and scalp conditions. Pattern hair loss in young men was shown to markedly impair quality of life, with a nine-item measure developed. In mice, engineered skin grafts regenerated skin with hair follicles, and boosting the gene ETV2 restored follicle blood vessels after chemotherapy.
- Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study In a 40-man trial, topical cetirizine 1% increased hair density in male pattern hair loss without adverse effects, though minoxidil 5% worked better.
- Hair Regrowth with Cannabidiol (CBD)-rich Hemp Extract – A Case Series In a 35-person uncontrolled case series, daily topical CBD-rich hemp oil for six months gave an average 93.5% increase in hair counts with no reported adverse effects.
- Undiagnosed cicatricial alopecia among new patients undergoing platelet-rich plasma Before starting PRP for pattern hair loss, patients should be evaluated for hidden scarring alopecia, which needs prompt immunomodulatory treatment instead.
- Evaluation of efficacy of intradermal injection therapy vs derma roller application for administration of QR678 Neo <sup>®</sup> hair regrowth formulation for the treatment of Androgenetic Alopecia—A prospective study In 50 AGA patients, intradermal QR678Neo injections gave somewhat better results than derma-roller delivery, but the derma roller was easier and less painful-free.
- CME article Part II. Hair transplantation: Surgical technique A review details hair transplant surgical techniques, covering anesthesia, FUT versus FUE harvesting, graft implantation, and complications.
- Hair transplantation: Basic overview A review explains modern follicular-unit hair transplantation and gives guidance on which patients and scalp conditions are good surgical candidates.
- Associations between clinical variables and treatment regimens and hair density and calibre in female androgenetic alopecia patients: a retrospective study of 602 patients a 602-patient retrospective study linking clinical variables and treatment regimens to hair density in female pattern hair loss.
- Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation In nude mice, engineered skin grafts made with skin-derived precursors regenerated skin with new hair follicles within three weeks.
- ER71/ETV2 Promotes Hair Regeneration from Chemotherapeutic Drug-Induced Hair Loss by Enhancing Angiogenesis In mice, boosting the vessel-growth gene ETV2 restored follicle blood vessels and improved hair regrowth after chemotherapy.
- Quality of life in young men with androgenetic alopecia: A mixed methods study Interviews and a 129-man survey show pattern hair loss markedly harms young men's quality of life, and a nine-item AGA-specific measure was developed.
- Treatment of pediatric alopecia areata: A systematic review A systematic review of 1032 pediatric alopecia areata patients found topical corticosteroids have the best evidence as first-line treatment.
- Indole Glycosides from <i>Calanthe discolor</i> with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells Indole glycosides isolated from an orchid stimulated human dermal papilla cell growth and raised VEGF and FGF-7 in lab cultures.
- A preliminary result of adipose derived stem cell treatment for female pattern hair loss preliminary results of adipose-derived stem cell treatment for female pattern hair loss.
- Topical tofacitinib for the treatment of alopecia areata affecting facial hair Topical tofacitinib was used to treat alopecia areata affecting facial hair.
- Association Between Vitamin D and Zinc Levels With Alopecia Areata Phenotypes at a Tertiary Care Center In 177 alopecia areata patients, 62.7% had low vitamin D, but levels did not correlate with disease pattern.
- Can antibiotic‐induced changes in the composition of the hair follicle microbiome regulate human hair growth? A pilot-study commentary asks whether antibiotics that alter the follicle microbiome could affect hair growth in pattern hair loss.
- Hair diameter measurements for planning follicular unit extraction surgery (FUE): Is there a correlation between the micrometer caliper and scanning electron microscopy (SEM) findings? In donor-area measurements, a manual micrometer caliper reliably gauged hair shaft diameter for planning FUE transplant surgery.
- Current insight into the functions of microRNAs in common human hair loss disorders: a mini review A review discusses microRNAs' roles in alopecia areata, pattern hair loss, and frontal fibrosing alopecia, though mechanisms remain unclear.
- Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles In a lab model of alopecia areata, mesenchymal stem cells restored outer root sheath cell viability and growth via Wnt and JAK/STAT pathways.
- Minoxidil-Coated Lysozyme-Shelled Microbubbes Combined With Ultrasound for the Enhancement of Hair Follicle Growth: Efficacy In Vitro and In Vivo In cell cultures and mice, minoxidil-coated lysozyme microbubbles plus ultrasound enhanced skin penetration and hair growth more than minoxidil alone.
- <i>Brassica oleracea</i> extract, glucosinlates, and sulforaphane promote hair growth in vitro and ex vivo In cell and mouse-follicle experiments, broccoli extract compounds countered testosterone's suppression of dermal papilla cells and promoted follicle growth.
- Comparing the delivery to the hair bulb of two fluorescent molecules of distinct hydrophilicities by different nanoparticles and a serum formulation In lab tests, a simple serum formulation delivered fluorescent molecules deeper into hair follicles than liposome or nanoparticle carriers.
- Is there a rationale for the use of botulinum toxin in the treatment of Androgenetic Alopecia? asks whether there is a rationale for using botulinum toxin to treat androgenetic alopecia.
- Hair regrowth in cicatricial alopecia: A literature review A review found 71 documented cases where hair regrew in scarring alopecia after treatment, though the mechanism is unknown.
- Micro-Current Stimulation Has Potential Effects of Hair Growth-Promotion on Human Hair Follicle-Derived Papilla Cells and Animal Model In cultured human papilla cells and mice, micro-current electrical stimulation activated growth pathways and promoted hair growth.
- Frontal Fibrosing Alopecia: A Review A review of frontal fibrosing alopecia notes rising prevalence and finds 5-alpha reductase inhibitors the most promising treatment.
- “Comparison of QR 678 ® & QR678 ® Neo as monotherapy and as combination therapy with 5% Minoxidil solution and oral Finasteride in the treatment of male androgenetic alopecia—Which is better?” a study comparing QR678 formulations alone and combined with minoxidil and finasteride in male AGA.
- Design of In Vitro Hair Follicles for Different Applications in the Treatment of Alopecia—A Review A review surveys methods for growing hair follicles in vitro and their potential uses in alopecia treatment and transplantation.
- Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis A review of human fetal hair follicle development aimed at building lab-grown skin substitutes containing hair follicles.
- Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata In AA-model mice, JAK1- and JAK3-selective inhibitors restored hair growth, while JAK2-selective inhibitors did not.
- Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed In cultured human papilla cells, linoleic acid from mallow seeds activated Wnt signaling, boosted growth factors, and inhibited the DHT-linked DKK-1.
- The effect of hyperbaric oxygen therapy combined with hair transplantation surgery for the treatment of alopecia Hyperbaric oxygen therapy combined with hair transplantation surgery was studied for treating alopecia.
- Prevalence of female pattern hair loss in a multiracial population a study of the prevalence of female pattern hair loss in a multiracial population.
- Conflicting Reports Regarding the Histopathological Features of Androgenic Alopecia: Are Biopsy Location, Hair Diameter Diversity, and Relative Hair Follicle Miniaturization Partly to Blame? A review argues conflicting AGA histology findings stem from poorly controlled biopsy location, hair diameter diversity, and miniaturization variables.
- Screening of hair growth promoting activity of Punica granatum L. (pomegranate) leaves extracts and its potential to exhibit antidandruff and anti-lice effect In mice, pomegranate leaf extracts induced the growth phase in 27-45% of animals versus 51% with minoxidil, plus anti-lice and antidandruff effects.
- Molecular docking studies and ADME-Tox prediction of phytocompounds from Merremia peltata as a potential anti-alopecia treatment In computer docking simulations, a Merremia peltata compound bound the androgen receptor more strongly than finasteride, suggesting anti-alopecia potential.