November 202129
Platelet-rich plasma in women was concluded an effective option for female pattern hair loss. Approved pattern hair loss treatments were found limited to minoxidil, finasteride and light therapy, with efficacy, side effects, compliance and cost compared. Bicalutamide for minoxidil hypertrichosis was reported to improve excess facial and body hair in treated women. Home-use low-level laser devices were found to improve hair density versus sham devices. Ferritin in women with nonscarring alopecia was found significantly lower, suggesting benefit from raising ferritin. Occipital biopsies in advanced AGA showed terminal-hair loss in the donor region. Autologous cellular micrografts were reported to raise hair density and thickness after one session.
- Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis A meta-analysis of 36 studies found women with nonscarring alopecia have significantly lower ferritin levels, suggesting benefit from raising ferritin.
- Systematic review: The platelet-rich plasma use in female androgenetic alopecia as effective autologous treatment of regenerative plastic surgery A systematic review of 5 studies concluded platelet-rich plasma is a safe and effective option for female pattern hair loss, without major side effects.
- Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics A review comparing all pattern hair loss treatments on efficacy, side effects, compliance and cost, noting only minoxidil, finasteride and light therapy are FDA-approved.
- Bicalutamide improves minoxidil-induced hypertrichosis in female pattern hair loss: A retrospective review of 35 patients bicalutamide improved minoxidil-induced excess facial and body hair in 35 women treated for female pattern hair loss.
- A Systematic Review and Meta-analysis of Randomized Controlled Trials of United States Food and Drug Administration-Approved, Home-use, Low-Level Light/Laser Therapy Devices for Pattern Hair Loss: Device Design and Technology. A meta-analysis of randomized trials found FDA-cleared home-use low-level laser devices improve hair density in pattern hair loss versus sham devices.
- Effectiveness of QR678 and QR678 Neo <sup>®</sup> with intralesional corticosteroid vs. intralesional corticosteroid alone in the treatment of alopecia areata –A randomized, comparative, prospective study In a 20-patient randomized study, QR678 Neo injections plus intralesional steroid improved alopecia areata more than steroid alone over 6 months.
- Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia Scalp biopsies showed men with advanced AGA also lose terminal hairs in the occipital region, so donor sites should be checked before transplant.
- Oral tofacitinib for the treatment of alopecia areata in pediatric patients In a retrospective series of 11 children with alopecia areata, oral tofacitinib produced hair regrowth in 8 with no serious adverse events.
- Transcutaneous application of ultrasound enhances the effects of finasteride in murine model of androgenic alopecia Low-intensity pulsed ultrasound doubled follicle counts and enhanced oral finasteride's hair growth effect in mice, without heating the skin.
- Cancer-Related Alopecia: From Etiologies to Global Management A review of cancer-treatment hair loss covering causes, cooling-cap prevention supported by randomized trials, and limited curative options.
- A Novel Follicular Unit Excision Device for All-Purpose Hair Graft Harvesting A new all-purpose follicular unit excision device handled diverse donor-hair scenarios successfully in early practitioner experience.
- Short-Term Efficacy of Autologous Cellular Micrografts in Male and Female Androgenetic Alopecia: A Retrospective Cohort Study A single autologous cellular micrograft session modestly raised hair density and thickness in 140 AGA patients, with ~66% showing favorable response.
- Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles and Dermal Papilla Cells Topical resveratrol promoted hair growth in mice, lengthened human hair follicles ex vivo and protected dermal papilla cells from oxidative damage.
- May the best wound WIHN: the hallmarks of wound-induced hair neogenesis A review of wound-induced hair neogenesis in mice, covering the cell types and pathways enabling adult follicle regeneration.
- The Rise of Induced Pluripotent Stem Cell Approach to Hair Restoration A review outlining how induced pluripotent stem cells could generate new hair follicles, so far shown only in mouse xenografts.
- The comparison of demographics and comorbidities of female pattern hair loss according to the clinical subtype and stage Advanced female pattern hair loss was linked to older age, menopause and hypertension; hirsutism and acne were commoner in Ludwig and Hamilton subtypes.
- Psychological Aspects of Hair Disorders: Consideration for Dermatologists, Cosmetologists, Aesthetic, and Plastic Surgeons A review urging dermatologists to address psychological aspects of hair loss and integrate psychodermatology into care.
- Economic Impact of Home-Use versus Office-Use Diphenylcyclopropenone in Extensive Alopecia Areata In a retrospective cohort of severe alopecia areata patients, home-use DPCP gave similar regrowth to clinic use at half the cost.
- Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study Serum CCL7 correlated with alopecia areata severity in 60 patients, suggesting a possible link to atherosclerosis risk.
- Evaluation of a new‐formula shampoo containing 6% glycyrrhetinic acid complex for scalp seborrheic dermatitis: A pilot study In a 34-patient pilot, a 6% glycyrrhetinic acid shampoo improved scalp seborrheic dermatitis scores and reduced Malassezia over five weeks.
- The potential role of hsa_circ_0001079 in androgenetic alopecia via sponging hsa‐miR‐136‐5p Sequencing of AGA follicles found hsa_circ_0001079 highly expressed, a candidate biomarker that may sponge miR-136-5p.
- The inflammatory component of androgenetic alopecia a review of the inflammatory component of androgenetic alopecia.
- PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair PBX1 overexpression reduced senescence and apoptosis of hair follicle mesenchymal stem cells by limiting ROS-mediated DNA damage.
- Research on Mental Stress Recognition of Depressive Disorders in Patients With Androgenic Alopecia Based on Machine Learning and Fuzzy K-Means Clustering A machine-learning algorithm identified depression in hair loss patients and psychological intervention improved depression scores in 54 patients.
- Overexpression of miR‐122 promotes apoptosis of dermal papilla cells by directly targeting IGF1R in androgenetic alopecia miR-122, elevated in balding follicles, kills dermal papilla cells in vitro by suppressing IGF1R, a possible AGA mechanism.
- Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway Oral Paeonia and Poria extracts restored hair growth in testosterone-treated mice by lowering testosterone and inflammatory signalling.
- Effect of PTPN22, FAS/FASL, IL2RA and CTLA4 genetic polymorphisms on the risk of developing alopecia areata: A systematic review of the literature and meta-analysis A meta-analysis found the PTPN22 rs2476601 T allele associated with increased alopecia areata risk, though further studies are needed.
- A clinico-trichological study of female androgenetic alopecia In 50 women with FAGA, trichoscopy features correlated with clinical severity; thyroid and ferritin levels were not necessarily abnormal.
- Serum paroxonase 1 level may be an indicator and predictor of the severity of androgenetic alopecia Serum paraoxonase 1 was significantly lower in AGA patients than controls and may indicate severity, supporting an oxidative-stress role.