May 202134
Higher-dose PRP was found to raise hair density and diameter in pattern hair loss, while a meta-analysis found PRP in women improved density despite lacking standardized protocols. Adding laser therapy to 5% minoxidil gave no extra growth, though pulsed light therapy boosted 2% minoxidil to match 5% efficacy. Most women using 5% topical minoxidil reported satisfaction despite ongoing life impact. Iontophoresis-delivered growth factors improved density and thickness in pattern hair loss with telogen effluvium. Long-hair follicular excision achieved low transection rates, a caffeine foam reduced telogen rate without increasing density, and rosuvastatin-treated men showed worsened insulin sensitivity.
- The Effects of Lower vs Higher Cell Number of Platelet-Rich Plasma (PRP) on Hair Density and Diameter in Androgenetic Alopecia (AGA): A Randomized, Double-Blinded, Placebo, Parallel-Group Half-Scalp IRB-Approved Study. In an 8-subject half-scalp trial, higher and lower platelet doses of PRP both raised hair density and diameter, with a trend favoring higher doses.
- Efficacy of Minoxidil Combined With Photobiomodulation for the Treatment of Male Androgenetic Alopecia. A Double‐Blind Half‐Head Controlled Trial A 21-man half-head trial found adding low-level laser therapy to 5% minoxidil gave no extra hair growth over minoxidil alone at 6 months.
- Low‐Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% to Bring a Sustainable Hair Regrowth Activity In two clinical studies, daily pulsed light therapy reduced scalp inflammatory markers and boosted minoxidil 2% regrowth to match 5% minoxidil efficacy.
- Platelet-Rich Plasma in Female Androgenic Alopecia: A Comprehensive Systematic Review and Meta-Analysis A meta-analysis of 42 studies found platelet-rich plasma improves hair density in female pattern hair loss, though standardized protocols are still lacking.
- Long hair follicular unit excision: personal experience A 134-patient series reports long-hair follicular unit excision achieved a 9.2% transection rate and 2.23 follicles per graft.
- The Effectiveness and Tolerability of Preformed Growth Factors Vehiculated Through Iontophoresis on Patients with Androgenetic Alopecia and Telogen Effluvium: A Clinical Study In 60 patients with pattern hair loss plus telogen effluvium, iontophoresis-delivered growth factors improved density and shaft thickness with no serious side effects.
- Sublingual tofacitinib for alopecia areata: a roll‐over pilot clinical trial and analysis of pharmacokinetics In an 18-patient pilot trial, sublingual tofacitinib gave a 37.5% response rate in treatment-resistant alopecia areata with a longer half-life than oral dosing.
- Cardiometabolic Risk Factors in Rosuvastatin-Treated Men with Mixed Dyslipidemia and Early-Onset Androgenic Alopecia Men with early-onset pattern hair loss on rosuvastatin showed smaller lipid and inflammation improvements and worsened insulin sensitivity compared with peers without hair loss.
- Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product: Results of a randomized, prospective, vehicle‐controlled double‐blind study in men In a 62-man trial, a caffeine-containing cosmetic foam reduced the telogen rate versus vehicle but did not significantly increase hair density over vehicle at 6 months.
- Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls In 31 men with pattern hair loss, vertex scalp showed higher surface lipids and lower hydration than occipital scalp, correlating with severity.
- Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence A review covers new topical formulation technologies — nanoparticles, microneedling, iontophoresis — aimed at improving drug delivery for alopecia.
- Patient Satisfaction and Quality of Life Among Adult Women with Androgenetic Alopecia Using 5% Topical Minoxidil. In 31 women using 5% topical minoxidil for at least six months, 84% reported satisfaction despite hair loss still affecting daily and social life.
- Follicular unit extraction [FUE] – One procedure, many uses A review describes follicular unit extraction as a versatile, relatively scarless transplant technique usable for pattern hair loss and other indications.
- Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia:<i>ex vivo</i>permeation and clinical appraisal CoQ10-loaded transethosomes penetrated skin better than plain CoQ10 solution and showed better clinical response in a small group of pattern hair loss patients.
- Hair Transplantation and Follicular Unit Extraction placeholder
- Anti-Inflammatory, Thrombolytic and Hair-Growth Promoting Activity of the n-Hexane Fraction of the Methanol Extract of Leea indica Leaves A Leea indica leaf fraction applied to mice significantly increased hair length and regrowth, with compounds predicted to bind PGD2 synthase.
- Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls A review summarizes the challenges and strategies for bioengineering human hair follicles and regenerative skin models.
- Mild-to-moderate COVID-19 is not associated with worsening of alopecia areata: A retrospective analysis of 32 patients In a 32-patient retrospective study, mild-to-moderate COVID-19 was not associated with worsening of pre-existing alopecia areata.
- Androgenetic alopecia and COVID ‐19: A review of the hypothetical role of androgens A review examines hypotheses linking androgens, pattern hair loss, and COVID-19 severity, without drawing firm conclusions.
- A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia? A hypothesis paper proposes caveolin-1 as a therapeutic target in frontal fibrosing alopecia, a scarring alopecia.
- Hair Transplantation in Burn Scar Alopecia After Combined Non-Ablative Fractional Laser and Microfat Graft Treatment In 13 patients, fractional laser plus microfat grafting before transplantation gave 76–95% graft survival in burn scar alopecia.
- Clinical Patterns of Hair Loss in Men A review outlines pathways and comorbidities linked to male pattern hair loss and emerging therapeutic targets.
- Understanding Causes of Hair Loss in Women A review outlines causes of hair loss in women and restoration options including transplantation, PRP, lasers, and stem cells.
- Topical and nutricosmetic products for healthy hair and dermal antiaging using “dual‐acting” (2 for 1) plant‐based peptides, hormones, and cannabinoids A review explores plant-based peptides, cytokinins, and cannabinoids as dual-acting cosmetic alternatives for skin antiaging and hair health.
- Hair transplantation Follicular Unit Excision (FUE): Introducing the multipurpose octagonal ring punch A description of a novel octagonal ring punch for follicular unit excision usable across varied skin and hair types.
- Androgenetic alopecia in women and men is not related to COVID‐19 infection severity: a prospective cohort study of hospitalized COVID‐19 patients In 118 hospitalized COVID-19 patients, pattern hair loss presence or severity did not correlate with ICU admission, intubation, or death.
- Genetic correlation analysis does not associate male pattern baldness with COVID-19 a genetic correlation analysis finds no association between male pattern baldness and COVID-19.
- Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice In laboratory and spiny mice, wound-induced hair follicle regeneration is governed by tissue stiffness fields mediated by the Twist1 pathway.
- Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia In cultured dermal papilla cells, the transcription factor FOXC1 was found to drive SFRP1 expression, which is elevated in androgenetic alopecia follicles.
- Role of scalp health in achieving optimal hair growth and retention A review plus treatment study found impaired scalp condition worsens hair quality, reversibly, via oxidative stress damaging the hair cuticle.
- Hair of the mouse: A skin bacteria “cocktail” gets follicles back on their feet A commentary highlights mouse work showing skin bacteria promote hair follicle neogenesis after wounding via keratinocyte IL-1R1 signaling.
- Effects of UV Induced-Photoaging on the Hair Follicle Cycle of C57BL6/J Mice In mice, UVA photoaged hair follicles causing miniaturization and gray hairs, while UVB up-regulated Wnt signaling and prolonged the hair cycle.
- Eyebrow Transplantation Using Long Hair Follicular Unit Excision Technique In 36 patients, long-hair follicular unit excision gave natural eyebrow transplant results with high satisfaction and no adverse events.
- Unexpected hair regrowth in a woman with longstanding Alopecia universalis