September 201832
A review of finasteride's history found it arrests hair loss in over 80% of men after 12 months, though controversy over sexual side effects deters many who could benefit. PRP for androgenetic alopecia was supported with a proposed treatment protocol, though preparation and evaluation methods remain unstandardized. Low-dose daily aspirin cut predicted topical minoxidil responders from 50% to 27% by inhibiting follicular sulfotransferase. In a trial in women, topical finasteride plus minoxidil beat minoxidil alone for hair diameter, though serum DHT fell, limiting use to postmenopausal women. A review of FDA 510(k) records found 47 laser devices cleared with indications outpacing evidence. In human follicles grown ex vivo, a sandalwood odorant prolonged hair growth. Melatonin in lipid carriers improved density and thickness versus melatonin solution.
- Controversies in the treatment of androgenetic alopecia: The history of finasteride A review notes finasteride arrests hair loss in over 80% of men after 12 months, but controversy over sexual side effects deters many who could benefit.
- Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C’s of oral therapy A case series of patients prescribed oral minoxidil 1.25 mg nightly for pattern or traction alopecia details tolerability and adherence, noting patients with cardiac comorbidities or hypotension were excluded.
- Platelet-rich plasma for androgenetic alopecia: A review of the literature and proposed treatment protocol A review finds PRP a promising AGA treatment and proposes a protocol, while noting preparation and evaluation methods remain unstandardized.
- Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients In 24 adults, 14 days of low-dose aspirin cut predicted topical minoxidil responders from 50% to 27% by inhibiting follicular sulfotransferase.
- Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study In a 30-woman trial, topical 0.25% finasteride plus 3% minoxidil beat minoxidil alone for hair diameter, though serum DHT fell, so use is limited to postmenopausal women.
- Shedding light on the FDA’s 510(k) approvals process: low-level laser therapy devices used in the treatment of androgenetic alopecia A review of FDA 510(k) records finds 47 low-level laser devices cleared for AGA with expanding indications that outpace evidence and may mislead consumers.
- Association of Hair Loss With Health Utility Measurements Before and After Hair Transplant Surgery in Men and Women In a survey of 308 laypeople, hair loss lowered health utility scores and the post-transplant state scored significantly higher than untreated alopecia for both sexes.
- Thiosulfate promotes hair growth in mouse model In mice, sodium thiosulfate accelerated hair growth, acted additively with minoxidil, and may work partly via vasorelaxation and H2S.
- Systemic treatments for alopecia areata: A systematic review A systematic review of 16 RCTs found only oral prednisolone pulse therapy and inosiplex supported for alopecia areata; evidence is weak overall and relapse rates considerable.
- The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance A review proposes plant compounds may help AGA by inhibiting 5a-reductase, calming scalp microinflammation and improving insulin resistance.
- A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia A review of 34 patients found hair transplantation gave moderate-to-positive results in most cases of primary scarring alopecia, though publication bias is a concern.
- Olfactory receptor OR2AT4 regulates human hair growth In human hair follicles grown ex vivo, a synthetic sandalwood odorant stimulating the OR2AT4 receptor prolonged hair growth; blocking the receptor stopped it.
- Clinical cosmeceutical repurposing of melatonin in androgenic alopecia using nanostructured lipid carriers prepared with antioxidant oils In a small clinical study, melatonin delivered in nanostructured lipid carriers improved hair density and thickness and reduced hair loss versus melatonin solution in AGA patients.
- Differential expression of mTOR signaling pathway proteins in lichen planopilaris and frontal fibrosing alopecia In scalp biopsies, mTOR signaling protein expression is altered in hair follicles of lichen planopilaris and frontal fibrosing alopecia patients.
- Feature characterization of scarring and non-scarring types of alopecia by multiphoton microscopy In 17 subjects, multiphoton microscopy non-invasively distinguished scarring from non-scarring alopecia by follicle size and inflammation.
- Restoration of hair-inductive activity of cultured human follicular keratinocytes by co-culturing with dermal papilla cells In a lab study, co-culturing human outer root sheath cells with dermal papilla cells restored their ability to induce hair in mice.
- Rethinking the classification of alopecia areata A proposal to rethink the classification of alopecia areata.
- A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle In mice, the Tgf-β co-receptor Endoglin helps switch hair follicles between growth and rest via Wnt/Bmp crosstalk.
- Efficacy of an agonist of<i>α</i>-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation A biomimetic peptide (PTP20) activated melanogenesis in follicle cells and, in 15 volunteers, boosted pigmentation markers after three months of lotion use.
- Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes In vitro, cystine-thiamin combination boosted keratinocyte proliferation and reduced UV-induced damage in growth-limited cells.
- Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery A lab study: oleic acid nanovesicles gave up to 10-fold higher follicular minoxidil deposition than standard lotion in skin models.
- Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways In mouse and follicle cultures, mackerel-derived fermented fish oil and its DHA promoted hair growth by activating anagen pathways in dermal papilla cells.
- Medicinal Plants for the Treatment of Hair Loss and the Suggested Mechanisms A review surveys medicinal plants and traditional Chinese remedies proposed for hair loss and their suggested mechanisms.
- Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms A review examines how ginseng and its metabolites might prevent hair loss, based largely on preclinical studies.
- Engineering the niche for hair regeneration — A critical review A review examines nanomaterial and stem-cell strategies for engineering the hair follicle niche, noting many hurdles remain.
- Morroniside regulates hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway In mice, morroniside accelerated anagen onset and delayed catagen via Wnt/beta-catenin signaling.
- Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development In mice, EGFR restrains Wnt/beta-catenin signaling to coordinate proliferation and differentiation during hair follicle development.
- Tofacitinib for the treatment of alopecia areata in preadolescent children Tofacitinib was used to treat alopecia areata in preadolescent children.
- Ruxolitinib for the treatment of severe alopecia areata Ruxolitinib was used to treat severe alopecia areata.
- Skin-permeable liposome improved stability and permeability of bFGF against skin of mice with deep second degree scald to promote hair follicle neogenesis through inhibition of scar formation In mice with deep scalds, a permeable bFGF liposome promoted hair follicle regrowth by inhibiting scar formation.
- Embryonic-like regenerative phenomenon: wound-induced hair follicle neogenesis A review summarizes what is known about wound-induced hair follicle neogenesis and its cellular and molecular mechanisms.
- Marking of temporal point and lower border of temporal triangle in planning hair transplantation for male-pattern baldness In a 126-patient case series, a new marking method placed the temporal point and temporal triangle border more aesthetically in Indian hair transplant patients.