August 201836
Finasteride's link with erectile dysfunction was found stronger in prostate studies than in pattern hair loss studies, though evidence remains limited and long-term sexual side effects warrant discussion. In pattern hair loss, 1,550-nm fractional laser over 12 sessions was reported to increase hair density and shaft diameter. In transplantation, harvested grafts counted against estimates contained more one-hair and fewer three-hair units than predicted. For alopecia universalis, topical tofacitinib and ruxolitinib produced partial regrowth, though clobetasol worked more often. A meta-analysis found contact immunotherapy in alopecia areata produced some regrowth in 65.5% of patients but complete regrowth in only 32.3%. In breast cancer patients, permanent chemotherapy-induced alopecia affected about 42% and was more common after taxane regimens.
- Minoxidil in the treatment of androgenetic alopecia A review summarizes the pivotal approval studies and recent developments in minoxidil, the only approved topical drug for male and female pattern hair loss.
- Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia A review found most studies link finasteride for enlarged prostate with erectile dysfunction, but most studies in pattern hair loss patients do not; evidence remains limited, so doctors should discuss possible long-term sexual side effects.
- Treatment of alopecia universalis with topical Janus kinase inhibitors – a double blind, placebo, and active controlled pilot study In a 16-patient trial, topical tofacitinib and ruxolitinib produced partial regrowth in alopecia universalis, though clobetasol worked more often.
- Oil body bound oleosin-rhFGF9 fusion protein expressed in safflower (Carthamus tinctorius L.) stimulates hair growth and wound healing in mice In mice, a safflower-produced oleosin-FGF9 fusion protein applied to skin promoted thicker hair growth and faster wound healing, partly via β-catenin.
- Complementary and Alternative Treatments for Alopecia: A Comprehensive Review A review found few complementary and alternative hair-loss treatments are backed by multiple randomized trials, and supplements lack regulation and standardization.
- Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study In breast cancer patients followed 3 years, permanent chemotherapy-induced alopecia affected about 42% and was more common after taxane regimens.
- Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia In 23 patients with pattern hair loss, 12 sessions of 1,550-nm fractional laser increased hair density and shaft diameter.
- Harvested vs estimated follicular units in hair transplantation In 65 hair-transplant patients, actual harvested grafts contained more one-hair and fewer three-hair follicular units than estimated preoperatively.
- Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata A meta-analysis of 45 studies (2227 patients) found contact immunotherapy produced some hair regrowth in 65.5% of alopecia areata patients, but complete regrowth in only 32.3%, with worse outcomes in extensive disease.
- Impact on Quality of Life in Patients who came with Androgenetic Alopecia for Hair Transplantion Surgery in a Clinic A survey of 120 hair-transplant patients found pattern hair loss had a small overall effect on quality of life, with self-consciousness affected most.
- Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling In cashmere goats, methylome sequencing identified four genes linked to the telogen-to-anagen hair-cycle transition.
- Comparison of quality of life in patients with androgenetic alopecia and alopecia areata a study compares quality of life in patients with androgenetic alopecia and alopecia areata.
- Translation into Portuguese language (Brazil), transcultural adaptation and validation of the quality of life questionnaire in female pattern hair loss (WAA-QoL-BP) researchers translate and validate a Portuguese version of the female pattern hair loss quality-of-life questionnaire.
- Review of Hair Follicle Dermal Papilla cells as <i>in vitro</i> screening model for hair growth A review compiles how dermal papilla cells are used as in vitro screening models to test hair-growth promoting and inhibitory agents.
- Obstructive sleep apnea, low transferrin saturation levels, and male‐pattern baldness In a study of 932 men, sleep apnea combined with family history was linked to a sevenfold higher odds of male-pattern baldness, with low iron saturation possibly involved.
- Dengue Virus Infects Primary Human Hair Follicle Dermal Papilla Cells Dengue virus infects human dermal papilla cells in vitro, causing inflammation and cell death that may explain post-infection shedding.
- The disrupted balance between hair follicles and sebaceous glands in<i>Hoxc13</i>‐ablated rabbits Hoxc13-ablated rabbits lose hair and show fewer follicles with enlarged sebaceous glands, modeling human ectodermal dysplasia.
- Tight Junction barriers in human hair follicles – role of claudin-1 Human hair follicles have a tight-junction barrier, and loss of claudin-1 impairs barrier function and hair keratinocyte growth.
- Structural changes of hair shaft after application of chemical hair straighteners: Clinical and histopathological study In 30 women, chemical straightening smoothed hair and repaired cuticles but did not fix split ends and may cause side effects.
- Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody A lab study using a new monoclonal antibody found hair protein KAP8.1 concentrates in specific cortex regions of the hair shaft and may help control hair curvature.
- Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration In mice, Hoxc gene expression in dermal papilla cells controls regional hair follicle regeneration through Wnt signaling.
- Hair Biology A review of hair anatomy, physiology and aging, noting no existing agent can reverse the natural course of hair aging.
- Mesenchymal Stem Cells and Stromal Vascular Fraction for Hair Loss A review describes mesenchymal stem cells, stromal vascular fraction and fat grafting as promising but still investigational hair-loss therapies.
- Psychosomatic aspects of alopecia areata A review describes the reciprocal link between alopecia areata and psychological disorders, and identifies patients needing psychological support.
- Decorin promotes proliferation and migration of ORS keratinocytes and maintains hair anagen in mice In mice, decorin promoted proliferation of hair follicle keratinocytes and maintained the anagen growth phase via Wnt/β-catenin.
- Chemotherapy‐induced alopecia – the urgent need for treatment options commentary highlighting the urgent need for treatment options for chemotherapy-induced alopecia.
- Alopecia in Association with Malignancy: A Review A review summarizes hair abnormalities and alopecia occurring as paraneoplastic signs or consequences of cancer therapy.
- Real-World Observational Evaluation of Hair Thinning in Patients with Multiple Sclerosis Receiving Teriflunomide: Is It an Issue in Clinical Practice? In 38 teriflunomide patients, hair thinning was usually mild, began within 3 months, and 79% recovered fully while continuing the drug.
- Updates in therapeutics for folliculitis decalvans: A systematic review with evidence-based analysis a systematic review updating evidence-based treatments for folliculitis decalvans.
- Therapeutic Potential of Stem Cells in Follicle Regeneration A review discusses stem-cell strategies for hair follicle regeneration, including adipose-derived and Wharton's jelly stem cells, with advantages and limitations.
- Severe hair loss associated with psyc hotropic drugs in psychiatric inpatients—Data from an observational pharmacovigilance program in German-speaking countries In 404,000 psychiatric inpatients, severe drug-related hair loss was very rare (0.01%), with valproic acid carrying the highest risk.
- Nanotechnology advances for hair loss A review highlights nanoencapsulation systems that could improve targeted delivery and reduce side effects of hair-loss drugs.
- Psychological assessment in 355 Chinese college students with androgenetic alopecia In a survey of 355 Chinese college students with pattern hair loss, students scored worse on depression, interpersonal sensitivity and other psychological measures than controls.
- Frontal fibrosing alopecia – review of recent case reports and case series in PubMed A review of 932 published frontal fibrosing alopecia patients found a notably high coincidence with thyroid disease.
- An Excellent Response to Tofacitinib in a Pediatric Alopecia Patient: A Case Report and Review. An 8-year-old with alopecia universalis achieved complete scalp regrowth on oral tofacitinib 5 mg twice daily within 6 months.
- Platelet-Rich Plasma for Hair Loss