May 201822
Monthly PRP plus booster raised hair count more than quarterly sessions. A network meta-analysis ranked low-level laser therapy first for hair count, with PRP, finasteride, minoxidil and dutasteride roughly equal. Nutrafol in women with thinning hair increased terminal and vellus counts versus placebo. A systematic review found PRP preparation reporting too inconsistent to compare studies for efficacy. In human scalp follicles, blocking SFRP1 with WAY-316606 boosted hair shaft production and delayed regression. A hair-growth vector concept for implantation direction in East Asian women aims to prevent awkward growth angles in hairline surgery.
- Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial In a 40-patient trial, PRP given monthly for 3 sessions plus a booster raised hair count ~30% versus 7% with 2 quarterly sessions.
- Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis Network meta-analysis ranked low-level laser therapy best for hair count, with PRP, finasteride, minoxidil and dutasteride roughly equal; evidence quality mostly low.
- A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair. In a 6-month RCT of 40 women, the Nutrafol supplement significantly increased terminal and vellus hair counts versus placebo, with no reported adverse events.
- Systematic review of platelet-rich plasma (PRP) preparation and composition for the treatment of androgenetic alopecia A systematic review found PRP preparation reporting so inconsistent (only 21% full detail) that studies cannot be compared for efficacy.
- Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles In human scalp follicles, blocking the Wnt inhibitor SFRP1 with WAY-316606 boosted hair shaft production and delayed follicle regression.
- A novel concept for determining the direction of implanted hair in hairline correction surgery in East Asian women A new 'hair growth vector' concept for implantation direction aims to prevent awkward growth angles in hairline correction surgery in East Asian women.
- miR‑339‑5p negatively regulates loureirin A‑induced hair follicle stem cell differentiation by targeting DLX5 In rat hair follicle stem cells, miR-339-5p inhibited loureirin A-induced differentiation by targeting DLX5 and suppressing Wnt signaling.
- Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle Study examines how the Nrf2 pathway modulates substance P–induced mast cell activation in the human hair follicle.
- Alopecia areata and the gut—the link opens up for novel therapeutic interventions A review hypothesizes that intestinal permeability and gut inflammation may drive alopecia areata, suggesting gut-targeted interventions.
- Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice Costunolide, a plant compound, stimulated human dermal papilla cells and grew hair in mice via Wnt/β-catenin and 5α-reductase inhibition.
- Distinguishing immunohistochemical features of alopecia areata from androgenic alopecia CD3 staining best distinguishes alopecia areata from androgenetic alopecia on biopsy, with 87% specificity and 97% sensitivity.
- A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth This viewpoint argues AGA treatments should aim to reverse follicle miniaturisation by enlarging the dermal papilla, not just stimulate growth.
- Is methotrexate an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? A Critically Appraised Topic A critical appraisal found insufficient evidence that methotrexate maintains regrowth in alopecia totalis; regrowth of 20-90% reported in low-quality series.
- iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice In diabetic obese mice, blocking iNOS promoted hair regrowth, suggesting nitric oxide prolongs the resting phase under inflammation.
- Cellular therapy with human autologous adipose-derived adult cells of stromal vascular fraction for alopecia areata In 20 alopecia areata patients, scalp injections of fat-derived stromal cells increased hair density and diameter over 6 months.
- M2 macrophages promote wound-induced hair neogenesis In mice, M2 macrophages drive wound-induced hair regrowth by secreting growth factors like FGF2 and IGF1.
- Nature-derived lignan compound VB-1 exerts hair growth-promoting effects by augmenting Wnt/β-catenin signaling in human dermal papilla cells The plant compound VB-1 promoted human dermal papilla cell proliferation and hair shaft growth in culture via Wnt/β-catenin signaling.
- Photoprotective Effects of a Multifunctional Hair Care Formulation Containing Botanical Extracts, Vitamins, and UV Filters A 'Hair BB Cream' formulation protected hair strands from UV damage and improved strength and shine in lab tests.
- New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies In 60 people with chronic telogen effluvium, a N1-methylspermidine plus Sandalore lotion reduced shedding and raised hair density over 3 months.
- Effect of Follicular Unit Extraction on the Donor Area. FUE extraction removed about 35% of donor-area hair density, so surgery should be planned cautiously as donor density varies.
- Retrospective analysis of the application of fumaric acid esters in 13 patients with alopecia areata a retrospective analysis of fumaric acid esters in 13 patients with alopecia areata.
- Gas chromatography coupled to mass spectrometry characterization, anti-inflammatory effect, wound-healing potential, and hair growth-promoting activity of Algerian Carthamus caeruleus L (Asteraceae) An Algerian Carthamus caeruleus root extract promoted hair growth, wound healing and anti-inflammatory effects in mice.