July 201828
iL-PRF injections for androgenetic alopecia improved alopecia scores versus controls in a controlled trial. Melatonin vitamin C nanovesicles increased hair thickness and density versus melatonin solution. Topical finasteride with minoxidil beat minoxidil alone on density and diameter with minimal systemic absorption. A finasteride-minoxidil-injection combination improved photographs in all patients in a large uncontrolled series. Follicular sulfotransferase activity stayed stable during topical minoxidil treatment. High-androgen-index progestin contraceptives were found capable of causing hair loss in women, with alternatives offered. On safety, male pattern baldness and prostate cancer showed no overall link, though vertex baldness carried a 24% higher risk and heterogeneity was notable.
- Injectable Platelet-, Leukocyte-, and Fibrin-Rich Plasma (iL-PRF) in the Management of Androgenetic Alopecia In a controlled trial, two iL-PRF injections three months apart significantly improved androgenetic alopecia scores versus controls, with greater improvement in more severe cases.
- Melatonin vitamin C-based nanovesicles for treatment of androgenic alopecia: Design, characterization and clinical appraisal In AGA patients, topical melatonin-loaded vitamin C nanovesicles increased hair thickness and density and decreased hair loss versus melatonin solution.
- A randomized, double-blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in the treatment of male androgenetic alopecia In a 40-man RCT, 0.25% topical finasteride with 3% minoxidil beat minoxidil alone on density and diameter, with only ~5% plasma DHT reduction and no systemic adverse events.
- Alopecia due to high androgen index contraceptives A review explains how high-androgen-index progestin contraceptives can cause hair loss in women and offers alternatives for affected patients.
- Male pattern baldness and incidence of prostate cancer A meta-analysis of 15 studies found no overall baldness-prostate cancer link, but vertex baldness carried a 24% higher risk; heterogeneity was notable and confirmatory studies are needed.
- The effect of topical minoxidil treatment on follicular sulfotransferase enzymatic activity. In 120 subjects, follicular sulfotransferase activity — the marker predicting minoxidil response — stayed stable over the course of topical minoxidil treatment.
- Androgenetic Alopecia Treatment in Asian Men. In an 18,918-patient uncontrolled series, a finasteride/minoxidil/injection combination improved photos in all patients with 96% satisfaction at six months and 4.2% minor complications.
- Hair Loss After Laparoscopic Sleeve Gastrectomy In 50 sleeve gastrectomy patients, 56% lost hair by six months; those affected had lower zinc, B12, and folate levels.
- Persistent Alopecia in a Breast Cancer Patient Following Taxane Chemotherapy and Adjuvant Endocrine Therapy: Case Report and Review of Post-treatment Hair Loss in Oncology Patients with Breast Cancer A case report and review found taxane/endocrine-related persistent alopecia can occur in breast cancer patients and topical minoxidil may be reasonable treatment.
- JAK Inhibitors for Treatment of Alopecia Areata A review finds JAK inhibitors can reverse hair loss in moderate-to-severe alopecia areata, summarizing preclinical and clinical evidence.
- White and yellow dots as new trichoscopic signs of severe female androgenetic alopecia in dark skin phototypes In 129 women, yellow and white trichoscopic dots correlated with advanced stages of female androgenetic alopecia in dark skin phototypes.
- Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE−/− mice fed western diet In western-diet-fed ApoE-deficient mice, blocking glycosphingolipid synthesis with D-PDMP reversed skin inflammation, hair discoloration, and hair loss.
- Dissociated skin cells regenerate hair follicles in a microwound, “The Punch Assay” In mice, a simple punch-wound assay regenerated hair follicles from dissociated mouse cells efficiently, while human cells formed follicles only with low efficiency on reconstituted human skin.
- Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data A study profiles gene expression in plucked hair follicles to clarify how AGA risk variants cause male hair loss.
- Comorbidities in alopecia areata: A systematic review and meta-analysis A meta-analysis of 87 studies found alopecia areata associated with atopic, thyroid, psychiatric and autoimmune diseases, urging comorbidity screening.
- Monitoring chemotherapy‐induced alopecia with trichoscopy An observational study defines the trichoscopic pattern of chemotherapy-induced alopecia and its evolution during and after treatment.
- Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib. In an 11-patient case series, oral tofacitinib produced marked regrowth in severe alopecia areata; one case responded to topical cream.
- Role of janus kinase inhibitors in the treatment of alopecia areata A review finds oral tofacitinib, ruxolitinib, and baricitinib promising in alopecia areata, while topical forms remain unsatisfactory.
- Female pattern hair loss A review explains that female pattern hair loss is the most common female alopecia, driven by follicle miniaturisation via androgens and DHT.
- Assessment of markers expressed in human hair follicles according to different skin regions Human follicle stem-cell marker K15 was highest in scalp compared with leg, abdomen, back, and waist skin.
- Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct In mice, loss of Gata6 dilated the hair canal and sebaceous duct but left hair largely normal.
- Interconnected PolymerS TeChnology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions In lab tests, a hyaluronic-acid/soy-protein patch with plant extracts inhibited 5α-reductase and appeared biocompatible for potential topical AGA use.
- An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation an integrated biomarker model of alopecia areata shows upregulation of both TH1 and TH2 pathways.
- Chronological clinicopathological characterization of rapidly progressive alopecia areata resistant to multiple i.v. corticosteroid pulse therapies: An implication for improving the efficacy In eight steroid-resistant rapidly progressive alopecia areata cases, repeat pulse therapy gave only partial, relapsing regrowth in three.
- The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells In mice, the dermal papilla niche triggers hair regeneration by releasing primed progenitors from quiescent stem-cell inhibition via Shh-Wnt cross talk.
- Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach In rat skin, a finasteride nano-transferosomal gel improved skin delivery of finasteride compared with a raw gel formula.
- [Expression of oleosin-rhFGF9 fusion protein in Carthamus tinctorius and determination of hair regeneration and wound repair potential in mice]. In mice, safflower-produced FGF9 fusion protein promoted hair regrowth and wound healing at high doses.
- Human long-term deregulated circadian rhythm alters regenerative properties of skin and hair precursor cells In shift-working women, long-term circadian disruption altered regenerative properties of skin and hair precursor cells.