Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/- Mice

This symposium discussed the role of lipids, inflammation, and stem cells in cicatricial alopecia but reports no new research findings; it highlights lipid pathways as significant in these hair disorders.

Hairless protein helps control hair growth by regulating vitamin D receptor activity.

This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

This study identified gene expression patterns in a mouse model that may influence tumor susceptibility and tissue functions related to inflammation and cell proliferation, highlighting Lgr5 and the vitamin D receptor as key regulators.

This study identified the Hairless (Hr) gene-encoded protein as a corepressor that plays a crucial role in maintaining skin and hair by regulating epithelial stem cell differentiation and gene expression via chromatin remodeling, which may impact both development and disease.

This study suggests that the vitamin D receptor and hairless gene may directly regulate each other via a transcriptional mechanism, potentially explaining phenotypic similarities between atrichia and VDRRIIa rickets.

This review discusses the role of the sonic hedgehog pathway in skin development and cancer, highlighting its potential as a target for chemoprevention and treatment; it reports no new findings.

This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.