Healthy Individuals Genetically At-Risk for the Development of Pemphigus Vulgaris or Alopecia Areata Share Disease-Like Cytokine Dysregulation

    January 2025 in “ Frontiers in Immunology ”
    Rebekah R. Schwartz, Kristina Seiffert-Sinha, Animesh A. Sinha
    Studysummary In this study, researchers found that cytokine dysregulation linked to genetic background is present in both patients and healthy but genetically related individuals in two autoimmune skin diseases, Pemphigus vulgaris and Alopecia areata, suggesting that protective immune mechanisms may prevent disease manifestation in predisposed individuals.
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    Research cited in this study 12

    1. Inheritance-Specific Dysregulation of Th1 and Th17-Associated Cytokines in Alopecia Areata Biomolecules · 2023
    2. The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications Cells · 2021
    3. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    4. Evaluation of the Level of Serum Interleukins (IL-2, IL-4, IL-15, and IL-17) and Its Relationship with Disease Severity in Patients with Alopecia Areata Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2021
    5. Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options Clinical and Experimental Medicine · 2021
    6. Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity British journal of dermatology/British journal of dermatology, Supplement · 2019
    7. An Integrated Model of Alopecia Areata Biomarkers Highlights Both TH1 and TH2 Upregulation Journal of Allergy and Clinical Immunology · 2018
    8. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    9. Th1/Th2 Peripheral Blood Balance and CD200 Expression in Patients with Active Severe Alopecia Areata Experimental and Therapeutic Medicine · 2017
    10. Altered Expression of Intracellular Toll-Like Receptors in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata BBA clinical · 2016
    11. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    12. Peripheral Blood Gene Expression in Alopecia Areata Reveals Molecular Pathways Distinguishing Heritability, Disease, and Severity Genes and Immunity · 2010