Interactions of the Vitamin D Receptor with the Corepressor Hairless

July 2007 in “ Journal of Biological Chemistry ”

Jining Wang, Peter J. Malloy, David Feldman

Vitamin D Receptor Hairless gene atrichia with papular lesions corepressor activity histone deacetylase 1 HR mutants VDR protein non-synonymous polymorphisms VDR HR gene APL HDAC1

Studysummary This study found that most pathogenic HR mutants associated with atrichia with papular lesions had abolished corepressor activity due to defective interactions with histone deacetylases.

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