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    Did you mean Tumor Suppressor Gene?
    Glossary Tumor Suppressor Gene

    regulates cell growth by preventing uncontrolled cell division

    A tumor suppressor gene is a type of gene that helps regulate cell growth by preventing cells from dividing too quickly or in an uncontrolled way. When these genes are mutated or inactivated, it can lead to the development of cancer because the normal checks on cell division are lost. Examples include the TP53 gene, which produces a protein that can trigger cell death if DNA damage is detected, thereby preventing the propagation of potentially cancerous cells.

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    1. The Vitamin D Receptor as Tumor Suppressor in Skin Advances in experimental medicine and biology · 2020 · 55 citations
    2. Roles of tumor suppressors in regulating tumor-associated inflammation Cell Death & Differentiation · 2014 · 44 citations
    3. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma Experimental Dermatology · 2016 · 8 citations
    4. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters Experimental Dermatology · 2016 · 6 citations
    5. Stem cell quiescence acts as a tumour suppressor in squamous tumours Nature Cell Biology · 2013 · 66 citations
    6. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment GenomeBiology.com · 2015 · 153 citations
    7. Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN Journal of the National Cancer Institute · 2012 · 81 citations
    8. Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis Carcinogenesis · 2006 · 37 citations
    9. The Tumor Suppressor Actions of the Vitamin D Receptor in Skin 2014 · 9 citations
    10. The Tumor Suppressor Actions of the Vitamin D Receptor in Skin 2013
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