28 citations
,
September 2008 in “Current Pharmaceutical Design” This review discusses hypersensitivity reactions to anticoagulants like ASA and heparins, highlighting their rare but potentially life-threatening nature, and emphasizes the need for meticulous allergy testing to find safe alternatives.
5 citations
,
May 2022 in “Clinical & Experimental Metastasis” This study found that minoxidil and ranolazine, individually and in combination, reduced cellular invasiveness in hypoxic triple-negative breast cancer cell lines, suggesting potential anti-metastatic effects at clinically relevant doses.
This review examines the physiology of skin flap necrosis and various substances studied to improve flap viability, noting that promising results are mostly from animal studies, with nitroglycerin already tested in humans.
January 2023 in “Side effects of drugs annual” This chapter reviews emerging side effects of various nutritional supplements and alternative medicine practices, highlighting potential toxicities and stressing the need for careful identification and management by healthcare professionals.
October 2024 in “Journal of the Endocrine Society” In this case report, a rare association between Cushing's syndrome caused by ectopic ACTH from cervical cancer is documented, highlighting the diagnostic challenges, treatment complexity, and high morbidity and mortality, with the patient succumbing to septic shock post-surgery.
2 citations
,
December 2017 in “Theriogenology” This study found that V-ATPase plays a role in the acidification of vas deferens fluid under the influence of testosterone in orchidectomized rats.
January 2025 in “JCEM Case Reports” This report describes two cases of glucocorticoid resistance syndrome highlighting genetic diversity; one patient improved with low-dose dexamethasone despite negative genetic testing, while the other is monitored with a novel NR3C1 variant.
August 2003 in “药物不良反应杂志” Combining finasteride and terazosin can cause severe allergic reactions.
20 citations
,
October 2003 in “The Journal of Dermatology” This study observed that while dexamethasone-cyclophosphamide pulse therapy is relatively free from hypertension and diabetes compared to conventional steroids in pemphigus patients, it frequently causes generalized weakness and flushing.
Thoracic medial branch block may be a simpler and effective alternative to thoracic vertebroplasty for pain management.
18 citations
,
January 1976 in “Clinical Science” This study found that minoxidil significantly reduced supine diastolic pressure in 94% of patients with severe essential hypertension within 4 weeks, but some patients experienced side effects such as increased hair growth and fatigue.
December 2025 in “Scientific Reports” This study found that preconditioning human hair follicle-derived stem cells with valproic acid enhanced their survival and migration in ischemic-like conditions by activating autophagy and inhibiting the AKT/mTOR pathway, suggesting this approach could improve stem cell therapies for ischemic stroke.
9 citations
,
November 2018 in “Acta Clinica Belgica” This case report suggests that spironolactone may induce prostate cancer proliferation in patients on abiraterone acetate, advising against its use for managing treatment-associated side effects in these individuals.
January 2007 in “UNIFESP Institutional Repository (Universidade Federal de São Paulo)” This study found that patients with chronic migraine who excessively use symptomatic medications had a higher prevalence of anxiety and mood disorders, suggesting these psychiatric diagnoses may influence medication overuse.
October 2009 in “Reactions Weekly” A woman developed lupus after taking hydroxyurea for two years.
3 citations
,
April 2017 in “Zahedan Journal of Research in Medical Sciences” This study observed that nearly all kidney transplant patients experienced complications from immunosuppressive therapy, with excessive hair growth and increased blood sugar being the most common issues.
31 citations
,
September 2014 in “Spinal Cord”
29 citations
,
October 1996 in “Toxicology and Applied Pharmacology” Higher minoxidil doses in dogs cause faster heart rate, lower blood pressure, and heart issues.
July 2023 in “Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ” The research investigated the effects of antiandrogens on neurodevelopmental milestones in rats exposed to valproic acid during pregnancy, finding that while valproic acid delayed sensorimotor reflexes, it didn't impact physical development milestones, and antiandrogens partially mitigated these delays.
January 1989 in “Side effects of drugs annual” This chapter reviews studies on the side effects of cytostatics and immunosuppressive drugs, detailing various toxicities such as cardiovascular, pulmonary, and neurotoxicity, but provides no new clinical results.
April 2014 in “Acta Medica Colombiana” This study presents a 63-year-old man with uncontrolled hypertension and facial hair who was diagnosed with adrenocortical adenoma, and whose blood pressure improved post-surgery.
7 citations
,
May 2017 in “Behavioural brain research” This study found that manipulating neuroactive steroids during early development stages in male rats influences alcohol-induced locomotor sensitivity, suggesting their role in addiction vulnerability.
36 citations
,
July 2005 in “Journal of Neuroendocrinology” This study suggests that both the central biosynthesis and metabolism of progesterone to 3α,5α‐THP in the ventral tegmental area are crucial for facilitating lordosis in female rats.
December 2023 in “Frontiers in pharmacology” In this study, intrathecal progesterone administration initially worsened mechanical allodynia in mice after nerve injury, but later reduced pain when applied during the maintenance phase, highlighting distinct roles for cytochrome P450c17 and 5α-reductase in neuropathic pain modulation.
1 citations
,
January 2010 in “Endocrine abstracts”
3 citations
,
August 2022 in “JAAD case reports” This review discusses the emerging evidence for low-dose oral minoxidil in treating various types of alopecia, without providing new clinical results.
3 citations
,
April 1991 in “PEDIATRICS” This reply argues that children with isolated extraordinary daytime frequency do not require extensive testing or aggressive pharmacologic treatments, noting potential negative effects of oxybutynin.
11 citations
,
January 2015 in “Dermatology” This study found multiple factors, both inherited and acquired, that may lead to bradykinin-mediated angio-oedema, proposing a new classification based on bradykinin production and catabolism imbalance.
47 citations
,
March 2019 in “Journal of immunology research” This review discusses the effects of valproic acid on immune cell activation and gene expression, potentially influencing infection outcomes and suggesting its promise for autoimmune and hypersensitivity condition management.
January 2024 in “Life sciences” This study observed that in spontaneously hypertensive rats, testosterone's effects on endothelium-dependent vasodilation involved reduced nitric oxide levels, increased oxidative stress, and greater reliance on endothelium-dependent hyperpolarization, with variations in these responses noted when testosterone was combined with either anastrozole or finasteride.