3 citations
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May 1994 in “Journal of Pharmacology and Experimental Therapeutics” This study found that minoxidil sulfate stimulates Cl channels, potentially depolarization-activated and outwardly rectifying, in eccrine clear cells, while minoxidil itself stimulates Ca-insensitive K currents.
October 2013 in “Journal of the American College of Cardiology” Blood pressure that doesn't drop at night is linked to worse blood vessel function in people with high blood pressure.
March 2026 in “Перспективи та інновації науки” This study reported that visceral massage improved skin elasticity and metabolic indicators such as glucose and lipid levels, suggesting its potential as a non-invasive method for enhancing skin health and systemic metabolism.
45 citations
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October 1988 in “British Journal of Clinical Pharmacology” This study found that topical minoxidil increased heart rate and had significant effects on cardiac volumes and mass compared to placebo, but its long-term safety remains uncertain.
August 2023 in “JAAD International” This study evaluated low dose oral minoxidil as a treatment for female pattern hair loss but reports no new clinical results.
1 citations
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June 2023 in “Frontiers in Pharmacology” This study found that hydralazine and minoxidil, two direct vasodilators, may worsen abdominal aortic aneurysm progression by increasing aortic degeneration and inflammation.
6 citations
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January 1988 in “PubMed” In this study, no changes in cutaneous blood flow were observed after applying 2%, 5%, or placebo minoxidil lotion in both androgenetic alopecia and healthy male volunteers.
3 citations
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May 2022 in “Journal of The American Academy of Dermatology” This source notes that while low-dose oral minoxidil is effective for treating androgenetic alopecia, it has been associated with electrocardiogram changes and palpitations even at low doses.
1 citations
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January 2025 in “World Journal of Emergency Medicine” This case report highlights a 37-year-old male who developed coronary vasospasm, resembling Prinzmetal angina, shortly after starting oral minoxidil for hair loss, emphasizing the need to consider drug-induced vasospasm in chest pain assessments even when coronary artery disease is absent.
1 citations
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March 2009 in “The Journal of Urology” This review discusses trials on therapies for benign prostatic hyperplasia and reports that combination treatment is more effective than monotherapy for symptom relief and slowing disease progression in men with moderate to severe symptoms and enlarged prostate glands.
18 citations
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July 1975 in “Clinical Pharmacology & Therapeutics” Oral minoxidil effectively controls blood pressure quickly and safely.
90 citations
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January 2003 in “The Journal of Urology” This study found that finasteride significantly reduced VEGF expression and microvessel density in prostatic suburethral tissue, suggesting a mechanism for decreased bleeding in patients with benign prostatic hyperplasia.
1 citations
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August 1989 in “Archives of Dermatology” This article reviews recent discoveries about the role of the nitroxide free radical NO in vascular physiology and suggests potential implications for minoxidil's vasodilatory action, but reports no new clinical findings.
January 2005 in “日本機械学會論文集. C編” This study suggests that minoxidil sulfate and pinacidil do not activate K channel currents in hair follicles, indicating their hair growth effects may occur through other mechanisms like increased blood flow.
This study found that finasteride reduces microvascular density and VEGF expression in the seminal vesicle tissue of rats.
February 2023 in “Clinical Toxicology” This letter to the editor raises concerns about minoxidil, an arterial vasodilator also used for androgenic alopecia, noting that overdose can cause severe side effects such as distributive shock, pulmonary edema, and myocardial ischemia.
55 citations
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June 2012 in “Steroids” This study found that testosterone modulates vascular cell behavior through direct actions that do not rely on its conversion to estradiol.
54 citations
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May 1977 in “The Journal of Pediatrics” Minoxidil helps lower high blood pressure in kids, but can cause fluid retention and hair growth.
January 2018 in “日本薬理学会年会要旨集 =” This study found that high-dose minoxidil, a potassium channel opener, may protect neuronal tissue from damage following transient focal cerebral ischemia in mice.
September 2008 in “Kitasato medical journal”
March 2026 in “Archives of Dermatological Research” Amlodipine cream may help hair growth by improving blood flow.
9 citations
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March 2016 in “Natural Product Research” This study found that baicalin promotes human microvascular endothelial cell proliferation, while visnadin and minoxidil enhance tubulogenesis, with hesperidin uniquely increasing VEGFR-2 phosphorylation compared to other compounds tested.
18 citations
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April 1998 in “MIT Press eBooks” This study found that topical application of N,N-dimethylglycine sodium salt increased dermal blood flow and velocity in human subjects, likely through its effects on endothelial cells and NO-dependent vasodilation.
5 citations
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February 2016 in “International Journal of Cancer” In this mouse study, applying a vasoconstrictor before chemotherapy did not create a leukemia sanctuary or significantly impact survival outcomes, suggesting it may not interfere with leukemia treatment.
1 citations
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February 1976 in “JAMA” In this article, the author reports a case where hemiballismus was almost completely suppressed within 48 hours of starting haloperidol therapy, suggesting a therapeutic response to the drug.
April 2026 in “Scientific Reports” This study found that perifollicular vascularization around the dermal papilla adjusts dynamically to physiological changes, with minoxidil enhancing vessel mobilization and aging processes inhibiting it, highlighting potential targets for treating hair loss and skin aging.
17 citations
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May 1975 in “Clinical Pharmacology & Therapeutics”
January 1983 in “Side effects of drugs annual” This chapter reviews adverse effects of anti-anginal and beta-blocker drugs, stating that starting a beta-blocker may temporarily affect driving ability, but it reports no new clinical findings.
This study evaluated local treatment with minoxidil 2% watery solution in patients with androgenetic alopecia but did not report detailed clinical outcomes.
January 2022 in “Social Science Research Network” This study found that most potassium channel blockers increased the activity of slowly adapting mechanoreceptors in rat whisker pads, while the opener NS1619 decreased their evoked activity.